(Bio Mathematical Lab of Sikander Aqeel)
CHAPTER [3] PROTEINS
Proteins
(3/24/2016)
Amino Acid Composition of Proteins:
It is amazing that all the different types of proteins are initially synthesized as polymers of only 20 amino acids, known as the common amino acids, the common amino acids are defined as those amino acids for which a specific codon exists in the DNA genetic code, there are 20 amino acids for which DNA codon are known, the process of the reading of the DNA code, resulting in the polymerization of amino acids of a specific sequence into the proteins based on the DNA code, In this chapter we shall discus only the protein of this genetically controlled synthetic process,
For example
Arginine = C6H14N4O2 = 177.5 m/g
Arginine = CGU, CGC, CGA, CGG, AGA, AGG = mRNA Codons
(GUANINE)
= a2 + b2 = c2 (Guanine)
= a2 = Arginine and b2 = Guanine = c2
= a2 = 177.5 m/g and b2 = 151.13 g/mol = c2
= a177.5 + b151.13 = c2
= 31506.25 + 22840.2769 = c2
= a + b = 54346.5269 = c2
= a + b = 54346.5269 / 44.950 (COO- + H0.9) = 1209.04
= a + b = 1209.04 / 151.13 (G) = 8
= a + b = 8 Guanine from Arginine polymerization,
mRNA Arginine Basic = 8 Guanine
tRNA Arginine Basic = 0 Guanine
(CYTOSINE)
= a2 + b2 = c2 (Cytosine)
= a2 = Arginine and b2 = Cytosine = c2
= a2 = 177.5 m/g and b2 = 111.1 g/mol = c2
= a177.5 + b111.1 = c2
= 31506.25 + 12343.21 = c2
= a + b = 43849.46 = c2
= a + b = 43849.46 / 78.936 (COOH + H1 + CH2 + NH3) = 555.5
= a + b = 555.5 / 111.1 (C) = 5
= a + b = 5 Cytosine from Arginine polymerization,
mRNA Arginine Basic = 5 Cytosine
tRNA Arginine Basic = 0 Cytosine
(URACIL)
= a2 + b2 = c2 (Uracil)
= a2 = Arginine and b2 = Uracil = c2
= a2 = 177.5 m/g and b2 = 112.0868 g/mol = c2
= a177.5 + b112.0868 = c2
= 31506.25 + 12563.45073424 = c2
= a + b = 44069.70073424 = c2
= a + b = 44069.70073424 / 393.479 (2C6H12O6 + N2) = 112
= a + b = 112 / 112 (U) = 1
= a + b = 1 Uracil from Arginine polymerization,
mRNA Arginine Basic = 1 Uracil
tRNA Arginine Basic = 0 Uracil
(ADENINE)
= a2 + b2 = c2
= a2 = Arginine and b2 = Adenine = c2
= a2 = 177.5 m/g and b2 = 135.13 g/mol = c2
= a177.5 + b135.13 = c2
= 31506.25 + 18260.1169 = c2
= a + b = 49766.3669 = c2
= a + b = 49766.3669 / 92.07 (2CHOH + N2) = 540.52
= a + b = 540.52 / 135.13 (A) = 4
= a + b = 4 Adenine from Arginine polymerization,
mRNA Arginine Basic = 4 Adenine
tRNA Arginine Basic = 0 Adenine
Total Codons = G8 + C5 + U1 + A4 = 18
Arginine = CGU, CGC, CGA, CGG, AGA, AGG = mRNA Codons
There are 20 amino acids for which mRNA codon are known, the process of the reading of the mRNA code, resulting in the polymerization of amino acids of a specific sequence into the proteins based on the mRNA code,
The genetically controlled synthetic process =
= (COO- + H1) or (CH3 – CH – CH3)
= (COOH + H1 + CH2 + NH3)
= (2C6H12O6 + N2)
= (2CHOH + N2)
Main Functions of Arginine:
Essential for normal immune system activity = (COOH + H1 + CH2 + NH3)
Necessary for wound healing = (COOH + H1 + CH2 + NH3)
Assists with regeneration of damaged liver = (2C6H12O6 + N2)
Necessary for production and release of growth hormone = (COOH + H1 + CH2 + NH3)
Increases release of insulin and glucagon = (2C6H12O6 + N2)
Arginine is the most potent amino acid in releasing insulin = (2CHOH + N2)
Assists in healing through collagen synthesis = (2C6H12O6 + N2)
Precursor to GABA, an important inhibitory neurotransmitter
Decreases size of tumors. (2C6H12O6 + N2) + (2CHOH + N2)
Necessary for **atogenesis = (COO- + H1) or (CH3 – CH – CH3)
The Uracil has most large amount of compounds (2C6H12O6 + N2), from reason of triplet (Phenylalanine)