(Bio Mathematical Lab of Sikander Aqeel)
CHAPTER [3] PROTEINS
Proteins
(3/26/2016)
Amino Acid Composition of Proteins:
It is amazing that all the different types of proteins are initially synthesized as polymers of only 20 amino acids, known as the common amino acids, the common amino acids are defined as those amino acids for which a specific codon exists in the DNA genetic code, there are 20 amino acids for which DNA codon are known, the process of the reading of the DNA code, resulting in the polymerization of amino acids of a specific sequence into the proteins based on the DNA code, In this chapter we shall discus only the protein of this genetically controlled synthetic process,
For example
Aspartic acid = C4H7NO4 = 134.75.75 m/g
Aspartic acid = GAU, GAC = mRNA Codons
(GUANINE)
= a2 + b2 = c2
= a2 = Aspartic acid and b2 = Guanine = c2
= a2 = 134.75 m/g and b2 = 151.13 g/mol = c2
= a134.75 + b151.13 = c2
= 18157.5625 + 22840.2769 = c2
= a + b = 40997.8394 = c2
= a + b = 40997.8394 / 135.63 (Glutamate + CH) = 302.27
= a + b = 302.26 / 151.13 (G) = 2
= a + b = 2 Guanine from Arginine polymerization,
mRNA Aspartic acid Basic = 2 Guanine
tRNA Aspartic acid Basic = 0 Guanine
(CYTOSINE)
= a2 + b2 = c2 (Cytosine)
= a2 = Aspartic acid and b2 = Cytosine = c2
= a2 = 134.75 m/g and b2 = 111.1 g/mol = c2
= a134.75 + b111.1 = c2
= 18157.5625 + 12343.21 = c2
= a + b = 30500.7725 = c2
= a + b = 30500.7725 / 274.53 (2-Asparagine + H6) = 111.1
= a + b = 111.1 / 111.1 (C) = 1
= a + b = 1 Cytosine from Aspartic acid polymerization,
mRNA Aspartic acid Polar = 1 Cytosine
tRNA Aspartic acid Polar = 0 Cytosine
(URACIL)
= a2 + b2 = c2 (Uracil)
= a2 = Aspartic acid and b2 = Uracil = c2
= a2 = 134.75 m/g and b2 = 112.0868 g/mol = c2
= a134.75 + b112.0868 = c2
= 18157.5625 + 12563.45073424 = c2
= a + b = 30721.01323424 = c2
= a + b = 30721.01323424 / 274.29 (2-Asparagine + H5) = 112
= a + b = 112 / 112 (U) = 1
= a + b = 1 Uracil from Aspartic acid polymerization,
mRNA Aspartic acid Polar = 1 Uracil
tRNA Aspartic acid Polar = 0 Uracil
(ADENINE)
= a2 + b2 = c2
= a2 = Aspartic acid and b2 = Adenine = c2
= a2 = 134.75 m/g and b2 = 135.13 g/mol = c2
= a134.75 + b135.13 = c2
= 18157.5625 + 18260.1169 = c2
= a + b = 36417.6794 = c2
= a + b = 36417.6794 / 134.75 (Asparagine) = 270.26
= a + b = 270.26 / 135.13 (A) = 2
= a + b = 2 Adenine from Aspartic acid polymerization,
mRNA Aspartic acid Polar = 2 Adenine
tRNA Aspartic acid Polar = 0 Adenine
Total Codons = G2 + C1 + U1 + A2 = 6
Aspartic acid = GAU, GAC = mRNA Codons
There are 20 amino acids for which mRNA codon are known, the process of the reading of the mRNA code, resulting in the polymerization of amino acids of a specific sequence into the proteins based on the mRNA code,
The genetically controlled synthetic process =
= (Glutamate + CH)
= (2-Asparagine + H6)
= (Asparagine)
= (Asparagine)
Main Functions of Aspartic acid:
Aspartic Acid is interconvertible with Asparagine = (2-Asparagine + H6)
And therefore the two amino acids have many functions in common = (Glutamate + CH)
Increases stamina = (3COOH) = 135.75
One of the two main excitatory amino acids = (Glutamate + CH) (Asparagine)
The other being Glutamate (Glutamic Acid) = (Glutamate + CH)
Helps protect the liver by aiding the removal of ammonia = (Glutamate + CH) (Asparagine)
Involved in DNA and RNA metabolism = (Glutamate + CH) (Asparagine)
Involved in immune system function by enhancing immunoglobulin production and anti- body formation.