(Bio Mathematical Lab of Sikander Aqeel)
CHAPTER [3] PROTEINS
Proteins
(3/28/2016)
Amino Acid Composition of Proteins:
It is amazing that all the different types of proteins are initially synthesized as polymers of only 20 amino acids, known as the common amino acids, the common amino acids are defined as those amino acids for which a specific codon exists in the DNA genetic code, there are 20 amino acids for which DNA codon are known, the process of the reading of the DNA code, resulting in the polymerization of amino acids of a specific sequence into the proteins based on the DNA code, In this chapter we shall discus only the protein of this genetically controlled synthetic process,
For example
Glutamine = C5H10N2O3 = 148.5 m/g
Glutamine = CAA, CAG = mRNA Codons
(GUANINE)
= a2 + b2 = c2
= a2 = Glutamine and b2 = Guanine = c2
= a2 = 148.5 m/g and b2 = 151.13 g/mol = c2
= a148.5 + b151.13 = c2
= 22052.25 + 22840.2769 = c2
= a + b = 44892.5269 = c2
= a + b = 44892.5269 / 297.04 (Glutamic Acid + Glutamine) = 151.13
= a + b = 151.13 / 151.13 (G) = 1
= a + b = 1 Guanine from Glutamine polymerization,
mRNA Glutamine Polar = 1 Guanine
tRNA Glutamine Polar = 0 Guanine
(CYTOSINE)
= a2 + b2 = c2 (Cytosine)
= a2 = Glutamine and b2 = Cytosine = c2
= a2 = 148.5 m/g and b2 = 111.1 g/mol = c2
= a148.5 + b111.1 = c2
= 22052.25 + 12343.21 = c2
= a + b = 34395.46 = c2
= a + b = 34395.46 / 154.79 (3(CH2OH + COOH + N) = 222.2
= a + b = 222.2 / 111.1 (C) = 2
= a + b = 2 Cytosine from Glutamine polymerization,
mRNA Glutamine Polar = 2 Cytosine
tRNA Glutamine Polar = 0 Cytosine
(ADENINE)
= a2 + b2 = c2
= a2 = Glutamine and b2 = Adenine = c2
= a2 = 148.5 m/g and b2 = 135.13 g/mol = c2
= a148.5 + b135.13 = c2
= 22052.25 + 18260.1169 = c2
= a + b = 40312.3669 = c2
= a + b = 40312.3669 / 99.44 (HPO4+ H2) = 405.39
= a + b = 405.39 / 135.13 (A) = 3
= a + b = 3 Adenine from Glutamine polymerization,
mRNA Glutamine Polar = 3 Adenine
tRNA Glutamine Polar = 0 Adenine
Total Codons = G1 + C2 + A3 + = 6
Glutamine = CAA, CAG = mRNA Codons
There are 20 amino acids for which mRNA codon are known, the process of the reading of the mRNA code, resulting in the polymerization of amino acids of a specific sequence into the proteins based on the mRNA code,
The genetically controlled synthetic process =
= (Glutamic Acid + Glutamine)
= (3(CH2OH + COOH + N)
= (HPO4+ H2)
Main Functions of Glutamine
Precursor to the neurotransmitter GABA =
This is a vital function =
As GABA is an inhibitory neurotransmitter that produces serenity and relaxation =
Important glycogenic amino acid = (HPO4+ H2)
Meaning that it is essential for helping to maintain normal and steady blood sugar levels = (HPO4+ H2)
Involved with muscle strength and indurance = (3(CH2OH + COOH + N)
Essential to gastrointestinal function =
Provides energy to the small intestines = (3(CH2OH + COOH + N)
The intestines are the only organ in the body that uses Glutamine as its primary source of energy = (3(CH2OH + COOH + N)
Glutamine has the highest blood concentration of all the amino acid = (HPO4+ H2)
Precursor to the neurotransmitter amino acid Glutamate (Glutamic Acid) = (Glutamic Acid + Glutamine)
Involved in DNA synthesis = (HPO4+ H2) + (HPO4+ H2)