(Bio Mathematical Lab of Sikander Aqeel)
CHAPTER [3] PROTEINS
Proteins
(3/29/2016)
Amino Acid Composition of Proteins:
It is amazing that all the different types of proteins are initially synthesized as polymers of only 20 amino acids, known as the common amino acids, the common amino acids are defined as those amino acids for which a specific codon exists in the DNA genetic code, there are 20 amino acids for which DNA codon are known, the process of the reading of the DNA code, resulting in the polymerization of amino acids of a specific sequence into the proteins based on the DNA code, In this chapter we shall discus only the protein of this genetically controlled synthetic process,
For example
Glutamate = C5H9NO4 = 149.25 m/g
Glutamate = GAA, GAG = mRNA Codons
(GUANINE)
= a2 + b2 = c2
= a2 = Glutamate and b2 = Guanine = c2
= a2 = 149.25 m/g and b2 = 151.13 g/mol = c2
= a149.25 + b151.13 = c2
= 22275.5625 + 22840.2769 = c2
= a + b = 45115.8394 = c2
= a + b = 45115.8394 / 99.50 (COOH + NH3 + CH2 + H2O + H3) = 453.42
= a + b = 453.42 / 151.13 (G) = 3
= a + b = 3 Guanine from Glutamate polymerization,
mRNA Glutamate Acidic = 3 Guanine
tRNA Glutamate Acidic = 0 Guanine
(ADENINE)
= a2 + b2 = c2
= a2 = Glutamate and b2 = Adenine = c2
= a2 = 149.25 m/g and b2 = 135.13 g/mol = c2
= a149.25 + b135.13 = c2
= 22275.5625 + 18260.1169 = c2
= a + b = 40535.6794 = c2
= a + b = 40535.6794 / 99.99 (3CH2OH + H3) = 405.39
= a + b = 405.39 / 135.13 (A) = 3
= a + b = 3 Adenine from Glutamate polymerization,
mRNA Glutamate Acidic = 3 Adenine
tRNA Glutamate Acidic = 0 Adenine
Total Codons = G3 + A3 + = 6
Glutamate = GAA, GAG = mRNA Codons
There are 20 amino acids for which mRNA codon are known, the process of the reading of the mRNA code, resulting in the polymerization of amino acids of a specific sequence into the proteins based on the mRNA code,
The genetically controlled synthetic process =
= (COOH + NH3 + CH2 + H2O + H3)
= (3CH2OH + H3)
Main Functions of Glutamate
Glutamic Acid is a precursor to Glutamine and GABA (2 neurotransmitters),
One of two excitatory neurotransmitters, the other being aspartic acid/asparagines,
Excesses in brain tissue can call cell damage, not damage by (3CH2OH + H3)
This is thought to be one of the mechanisms by why strokes kill brain cells;
That is through the release of large amounts of Glutamic Acid, stops the (3CH2OH + H3)
Helps stop alcohol and sugar cravings, (COOH + NH3 + CH2 + H2O + H3)
Increases energy, (3CH2OH + H3)
Accelerates wound healing and ulcer healing, by (3CH2OH + H3)
Detoxifies ammonia in the brain by forming glutamine, NH3
Which can cross the blood-brain barrier, which Glutamic Acid cannot do,
Plays important role in DNA synthesis, COOH carboxyl group of one amino acid molecule reacts with the amino group of the other amino acid molecule,