(Bio Mathematical Lab of Sikander Aqeel)
CHAPTER [3] PROTEINS
Proteins
(4/3/2016)
Amino Acid Composition of Proteins:
It is amazing that all the different types of proteins are initially synthesized as polymers of only 20 amino acids, known as the common amino acids, the common amino acids are defined as those amino acids for which a specific codon exists in the DNA genetic code, there are 20 amino acids for which DNA codon are known, the process of the reading of the DNA code, resulting in the polymerization of amino acids of a specific sequence into the proteins based on the DNA code, In this chapter we shall discus only the protein of this genetically controlled synthetic process,
For example
Leucine = C6H13NO2 = 134.25 m/g
Leucine = UUA, UUG, CUU, CUC, CUA, CUG, = mRNA Codons
(GUANINE)
= a2 + b2 = c2
= a2 = Leucine and b2 = Guanine = c2
= a2 = 134.25 m/g and b2 = 151.13 g/mol = c2
= a134.25 + b151.13 = c2
= 18023.0625 + 22840.2769 = c2
= a + b = 40863.3394 = c2
= a + b = 40863.3394 / 135.19 (134.25 Isoleucine) = 302.26
= a + b = 302.26 / 151.13 (G) = 2
= a + b = 2 Guanine for mRNA Leucine,
mRNA Leucine Non-polar = 2 Guanine
tRNA Leucine Non-polar = 0 Guanine
(CYTOSINE)
= a2 + b2 = c2
= a2 = Leucine and b2 = Cytosine = c2
= a2 = 134.25 m/g and b2 = 111.1 g/mol = c2
= a134.25 + b111.1 = c2
= 18023.0625 + 12343.21 = c2
= a + b = 30366.2725 = c2
= a + b = 30366.2725 / 54.66 (40 Ca + 14.66 N = 54.66) = 555.5
= a + b = 555.5 / 111.1 (C) = 5
= a + b = 5 Cytosine for mRNA Leucine,
mRNA Leucine Non-polar = 5 Cytosine
tRNA Leucine Non-polar = 0 Cytosine
(URACIL)
= a2 + b2 = c2
= a2 = Leucine and b2 = Uracil = c2
= a2 = 134.25 m/g and b2 = 112.0868 g/mol = c2
= a134.25 + b112.0868 = c2
= 18023.0625 + 12563.45073424 = c2
= a + b = 30586.51323424 = c2
= a + b = 30586.51323424 / 30.32 (N2 + H2) = 1008.7812
= a + b = 1008.7812 / 112.0868 (U) = 9
= a + b = 9 Uracil for mRNA Leucine,
mRNA Leucine Non-polar = 9 Uracil
tRNA Leucine Non-polar = 0 Uracil
(ADENINE)
= a2 + b2 = c2
= a2 = Leucine and b2 = Adenine = c2
= a2 = 134.25 m/g and b2 = 135.13 g/mol = c2
= a134.25 + b135.13 = c2
= 18023.0625 + 18260.1169 = c2
= a + b = 36283.1794 = c2
= a + b = 36283.1794 / 134.25 (Leucine 134.24) = 270.26
= a + b = 270.26 / 135.13 (A) = 2
= a + b = 2 Adenine for mRNA Leucine,
mRNA Leucine Non-polar = 2 Adenine
tRNA Leucine Non-polar = 0 Adenine
Total Codons = G2 + C5 + U9 + A2 + = 18
Leucine = UUA, UUG, CUU, CUC, CUA, CUG, = mRNA Codons
There are 20 amino acids for which mRNA codon are known, the process of the reading of the mRNA code, resulting in the polymerization of amino acids of a specific sequence into the proteins based on the mRNA code,
The genetically controlled synthetic process =
= (134.25 Isoleucine)
= (40 Ca + 14.66 N = 54.66)
= (N2 + H2)
= (Leucine 134.24)
Main Functions of Leucine
As one of the 3 branched-chain amino acids (the other 2 being Isoleucine and Valine),
Leucine has all of the properties discussed with Isoleucine, (134.25 Isoleucine)
as it pertains specifically to the branched-chain amino acid functions.
Potent stimulator of insulin, (134.25 Isoleucine)
Helps with bone healing, (40 Ca + 14.66 N = 54.66)
Helps promote skin healing, (40 Ca + 14.66 N = 54.66)
Modulates release of Enkephalins, which are natural pain-reducers, (Leucine 134.24)
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