(Bio Mathematical Lab of Sikander Aqeel)
CHAPTER [3] PROTEINS
Proteins
(5/24/2016)
Amino Acid Composition of Proteins:
It is amazing that all the different types of proteins are initially synthesized as polymers of only 20 amino acids, known as the common amino acids, the common amino acids are defined as those amino acids for which a specific codon exists in the DNA genetic code, there are 20 amino acids for which DNA codon are known, the process of the reading of the DNA code, resulting in the polymerization of amino acids of a specific sequence into the proteins based on the DNA code, In this chapter we shall discus only the protein of this genetically controlled synthetic process,
In addition to the common amino acids, derived amino acids are found in proteins, derived amino acids are found from one of the common amino acids, usually by an enzyme-facilitated reaction, after the common amino acids has been incorporated into the proteins structure, an example of a derived amino acids Cystine, other derived amino acids are desmosine and isodesmosine found in protein elastin,
The hydroxyTyrosine and hydroxylysine found in Collagen and Y-carboxyglutamate found in prothrombin,
Regular Structure of the Common Amino Acids,
The common amino acids have the regular structure, they contain on common a central (Alpha) carbon atom, to which a carboxyl acid group an amino group, and a hydrogen atom are covalently bonded, the (Alpha) a-carbon atom binds a side chain group designated R, that is different for each of the 20 amino acids,
TYROSINE
Regular Structure of the Common Amino Acids
----------COO-
----------|
----H3N – C – H Regular structure of common amino acids,
----------|
----------R
In the structure the ionized form for common amino acids that present in solution at 7.0 pH, is shown,
For example,
= a2 + b2 = c2
= a2 (NH3) + b2 (H) = c2
= a2 (17.75) + b2 (1.25) = c2
= a2 (315.0625) + b2 (1.5625) = c2
= a + b = 316.625 = c2
= a + b = 316.625 / 44 (COO-) = 7.19
= a + b = 7 = pH
TYROSINE
Regular + Biological Structure of the Tyrosine
= a2 + b2 = c2
= a2 (NH3) + b2 (H) = c2
= a2 (17.75) + b2 (1.25) = c2
= a2 (315.0625) + b2 (1.5625) = c2
= a + b = 316.625 = c2
= a + b = 316.625 / 17.7 = 17.7
= a + b = 17.7 + 25.75 (Alpha C + H11 = 25.75) = 43.45
= a + b = 43.45 + 48.425 (48 chromosomes of Potato) = 91.875 [Tyrosine present in Potato and in vegetables]
= a + b = 91.875 + 91.875 = 183.75
= a + b = 91.875 + R = 183.75
= a + b = 183.75 = Tyrosine (By Regular Structure of the Common Amino Acids)
Armotic
COO-
|
H3N – C - H Tyrosine = H11
|
CH2
|
C6H4
|
OH
Here Tyrosine = C + H11 = C9H11NO3
The a-amino is proton-ate and in its ammonium ion form: the carbonxylic acid group is in its unproton-ate or carboxyl ate form,
Reaction of Tyrosine
= a2 / b1 = c2
= a2 Tyrosine / b1 Time = c2
= a2 183.75 / b1 24 hours = c2
= a2 33764.0625 / b1 24 hours = c2
= a / b = 1406.83 = c2
= a / b = 1407 / 7 pH of water = 201
= a / b = 201 - 17.25 (OH of Tyr) = 183.75
= a / b = 183.75 = Tyrosine
So the Tyrosine dose treating of Depression, improves mental clarity, and concentration in 24 hours,
Main Functions of Tyrosine:
Improves mental clarity and concentration,
Depression
TYROSINE ENZYMES, HEAM, GLOBIN, AND HEMOGLOBIN
The enzymes are kind of Time-acids, the world of enzymes belongs with 48 hours of one day, if your age is 48 year today, that your enzymes has worked 96 years, and this process increases to age system, and from this reason the enzymes speed occurs faster for catalyst,
Tyrosine = 183.75 mole grams
Tyrosine enzymes = 48 hours time of dabble speed
= a2 + b2 = c2
= a Tyrosine + b time = c2
= a183.75 + b48 hours = c2
= a33764.0625 + b2304 = c2
= a + b = 36068.0625 = c2
= a + b = 36068.0625 / 189.91 = 189.92
Enzymes number = 189.92 * 189.92 = 36069.6064
Enzymes number = Time * Amino Acid = 36069.6064
Tyrosine enzymes number = 36069.6064
HEMOGLOBIN
ATP
Glucose 6-phosphate = 2.118 kcal
gene = 19 (19 * 0.008 Photons = 0.152)
= a2 + b2 = c2
= a Tyrosine + b time = c2
= a183.75 + b48 hours = c2
= a33764.0625 + b2304 = c2
= a + b = 36068.0625 = c2
= a + b = 36068.0625 * 1.788 = 64489.69575
= a + b = 64490 + 10 = 64500.00
= a + b = 64500.00 = molecular weight of hemoglobin
Here (1.788 kcal energy change during hydrolysis ATP) glucose 6-phosphate = 1.788 kcal`,
DIVISION OF HEAM AND GLOBIN
Heam = two Iron = Fe2 = 56 + 56 = 112
Globin = proteins = 576 polypeptide chain
Hemoglobin = 64500.00 / 112 Fe2 = 575.89
= 576 / 7.4 pH = 77.83
= 77.83 + 105.92 (CH2OH + CO2 = 107.5) = 183.75
= 183.75 = Tyrosine amino acids
DIVISION OF HEAM AND GLOBIN
Heam = two Iron = Fe2 = 56 + 56 = 112
Globin = proteins = 576 polypeptide chain
Hemoglobin = 64500.00 / 112 Fe2 = 575.89
= 576 / 3.134 (H3=G///C) = 183.75
= 183.75 = C9H11NO3 = Tyrosine
The Tyrosine = hormone of thyroid gland
Main Functions of Tyrosine:
Improves mental clarity and concentration,
Depression
Precursor to thyroxine and growth hormone,