(Bio Mathematical Lab of Sikander Aqeel)
CHAPTER [3] PROTEINS
Proteins
(6/14/2016)
Amino Acid Composition of Proteins:
It is amazing that all the different types of proteins are initially synthesized as polymers of only 20 amino acids, known as the common amino acids, the common amino acids are defined as those amino acids for which a specific codon exists in the DNA genetic code, there are 20 amino acids for which DNA codon are known, the process of the reading of the DNA code, resulting in the polymerization of amino acids of a specific sequence into the proteins based on the DNA code, In this chapter we shall discus only the protein of this genetically controlled synthetic process,
In addition to the common amino acids, derived amino acids are found in proteins, derived amino acids are found from one of the common amino acids, usually by an enzyme-facilitated reaction, after the common amino acids has been incorporated into the proteins structure,
Regular Structure of the Common Amino Acids,
The common amino acids have the regular structure, they contain on common a central (Alpha) carbon atom, to which a carboxyl acid group an amino group, and a hydrogen atom are covalently bonded, the (Alpha) a-carbon atom binds a side chain group designated R, that is different for each of the 20 amino acids,
HISTIDINE
Regular Structure of the Common Amino Acids
----------COO-
----------|
----H3N – C – H Regular structure of common amino acids,
----------|
----------R
In the structure the ionized form for common amino acids that present in solution at 7.0 pH, is shown,
For example,
= a2 + b2 = c2
= a2 (NH3) + b2 (H) = c2
= a2 (17.75) + b2 (1.25) = c2
= a2 (315.0625) + b2 (1.5625) = c2
= a + b = 316.625 = c2
= a + b = 316.625 / 44 (COO-) = 7.19
= a + b = 7 = pH
HISTIDINE
Regular + Biological Structure of the Histidine
= a2 + b2 = c2
= a2 (NH3) + b2 (H) = c2
= a2 (17.75) + b2 (1.25) = c2
= a2 (315.0625) + b2 (1.5625) = c2
= a + b = 316.625 = c2
= a + b = 316.625 / 17.7 = 17.7
= a + b = 17.7 + 23.25 (Alpha C + H9 = 23.25) = 40.95
= a + b = 40.95 + 37.675 (2H2O + 0.675 = 37.675) = 78.625 [Histidine Useful in treating anemia due to relationship to hemoglobin]
= a + b = 78.625 + 78.625 = 157.25
= a + b = 78.625 + R = 157.25
= a + b = 157.25 = Histidine (By Regular Structure of the Common Amino Acids)
Diamino, monocarboxylic
COO-
|
H3N – C - H Histidine = H9
|
CH2
|
CH
|
H - C - N
|
C
|
NH
Here Histidine = C + H9 = C6H9N3O2
The a-amino is proton-ate and in its ammonium ion form: the carbonxylic acid group is in its unproton-ate or carboxyl ate form,
Reaction of Histidine
= a2 / b1 = c2
= a2 Histidine / b1 Time = c2
= a2 157.25 / b1 24 hours = c2
= a2 24727.5625 / b1 24 hours = c2
= a / b = 1030.31 = c2
= a / b = 1030 / 7 pH of water = 147.14
= a / b = 147 - 10.25 (H8 = 10) = 157.25
= a / b = 157.25 = Histidine
So Histidine Assists in maintaining proper blood pH.
HISTIDINE ENZYMES, HEAM, GLOBIN, AND HEMOGLOBIN
The enzymes are kind of Time-acids, the world of enzymes belongs with 48 hours of one day, if your age is 48 year today, that your enzymes has worked 96 years, and this process increases to age system, and from this reason the enzymes speed occurs faster for catalyst,
Histidine = 157.25 mole grams
Histidine enzymes = 48 hours time of dabble speed
= a2 + b2 = c2
= a Histidine + b time = c2
= a157.25 + b48 hours = c2
= a 24727.5625 + b 2304 = c2
= a + b = 27031.5625 = c2
= a + b = 27031.5625 / 164.41 = 164.41
Enzymes number = 164.41 * 164.41 = 27030.6481
Enzymes number = Time * Amino Acid = 27030.6481
Histidine enzymes number = 27030.6481
HEMOGLOBIN
ATP
Glucose 6-phosphate = 2.386 kcal
Gene = 3 (3 * 0.008 Photons = 0.024)
= a2 + b2 = c2
= a Histidine + b time = c2
= a 157.25 + b48 hours = c2
= a 24727.5625 + b 2304 = c2
= a + b = 27031.5625 = c2
= a + b = 27031.5625 * 2.386 = 64497.308125
= a + b = 64497 + 3 = 64500.00
= a + b = 64500.00 = molecular weight of hemoglobin
Here (2.386 kcal energy change during hydrolysis ATP) glucose 6-phosphate = 2.386 kcal, One variation of Histidine namely Phosphotidyl Histidine
DIVISION OF HEAM AND GLOBIN
Heam = two Iron = Fe2 = 56 + 56 = 112
Globin = proteins = 576 polypeptide chain
Hemoglobin = 64500.00 / 112 Fe2 = 575.89
= 576 / 7.4 pH = 77.83
= 77.83 + 79.42 (PO2 + O = 79) = 157.25
= 157.25 = Histidine Associated with allergic response and has been used to treat allergy,
DIVISION OF HEAM AND GLOBIN
Heam = two Iron = Fe2 = 56 + 56 = 112
Globin = proteins = 576 polypeptide chain
Hemoglobin = 64500.00 / 112 Fe2 = 575.89
= 576 / 3.75 (H3= G///C) = 153.6
= 153.6 / 0.976 pH = 157.37
= 157.25 = C6H9N3O2 = Histidine
GENETIC CODE FROM HISTIDINE
16 permutation of four-Letter code taken by pairs
Human bones = 206
Human chromosomes = 46.25
Histidine = 157.25
Guanine = 151.13 g/mol = (G)
Human bones = 206 * 46.25 = 9527.5
= 9527.5 = total genetic codes of 206 bones,
= a2 + b2 = c2
= a2 genetic codes + b2 Histidine = c2
= a2 9527.5 + b2 157.25 = c2
= 90773256.25 + 24727.5625 = c2
= 90773256.25 + 24727.5625 = c2
= a + b = 90797983.8125 = c2
= a + b = 90797983.8125 / 9528.79 = 9528.80
= 9529 / 151.13 (G) = 63.05
= 63 / 10.5 gene = 6
= 6 = CAU CAC, Histidine genetic code
= genetic mutation = 10.5 gene by Histidine
= genetic mutation = 10.5 gene into the artery cells,
So 21 genes happening disorder per day by law of enzymes speed,
SEARCH OF GENETIC MUTATION
Enzymes speed = 120 minute (by 48 hours a day)
Guanine = 151.13
= a2 + b2 = c2
= a2 enzymes + b2 G = c2
= a2 120 + b2 151.13 = c2
= 14400 + 22840.2769 = c2
= 14400 + 22840.2769 = c2
= a + b = 37240.2769 = c2
= a + b = 37240.2769 / 192.97 = 192.98
= 193 / 9.19(H8) = 21
= 21 = gene,
So 7 genes happening disorder per day by law of enzymes speed,
61 TO 92 YEAR AGE
61 to 92 year age = 65 heartbeat per minute
Histidine = 157.25
= a2 + b2 = c2
= a2 Histidine + b2 heartbeat = c2
= a2 157.25 + b2 65 = c2
= 24727.5625 + 4225 = c2
= 24727.5625 + 4225 = c2
= a + b = 28952.5625 = c2
= a + b = 28952.5625 / 170.15 = 170.15
= 170.15 / 157.25 (Histidine) = 1.08
= 1.08 % (Histidine) in 61 to 92 year age,
31 TO 61 YEAR AGE
31 to 61 year age = 75 heartbeat per minute
Histidine = 157.25
= a2 + b2 = c2
= a2 Histidine + b2 heartbeat = c2
= a2 157.25 + b2 75 = c2
= 24727.5625 + 5625 = c2
= 24727.5625 + 5625 = c2
= a + b = 30352.5625 = c2
= a + b = 30352.5625 / 174.21 = 174.22
= 174.22 / 157.25 (Histidine) = 1.10
= 1.10 % (Histidine) in 31 to 61 year age,
1 TO 31 YEAR AGE
1 to 31 year age = 120 heartbeat per minute
Histidine = 157.25
= a2 + b2 = c2
= a2 Histidine + b2 heartbeat = c2
= a2 157.25 + b2 120 = c2
= 24727.5625 + 14400 = c2
= 24727.5625 + 14400 = c2
= a + b = 39127.5625 = c2
= a + b = 39127.5625 / 197.80 = 197.81
= 197.81 / 157.25 (Histidine) = 1.25
= 1.25 % (Histidine) in 1 to 31 year age,
The Histidine necessary to growth of tissues, and convert to glucose in glycogen in liver, and releases to hydrochloric acid in walls of stomach,
The heart beating rate of one year child is 120 times per minute, and heartbeat increases quantity of amino acids into the cells,
1.08 % (Histidine) will be called non effective
1.10 % (Histidine) will be called low effective
1.25 % (Histidine) will be called full effective
Full effective Histidine Found in high concentrations in hemoglobin, Useful in treating anemia due to relationship to hemoglobin, Has been used to treat rheumatoid arthritis, Precursot to histamine, Associated with allergic response and has been used to treat allergy,
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