Sikander Aqeel

CHROMOSOMES WITH BIO-CHEMISTRY

Jun 14th 2016, 11:03 am

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(Bio Algebra of Chromosomes)

(Mathematical Lab of Sikander Aqeel)

CHAPTER [3] PROTEINS

(6/15/2016)

Proteins:

46.25 Chromosomes and R Group:

Polar and A-polar Proteins of the Amino acid R Group:

It is important to have an appreciation for the relative hydrophobicity of the amino acids side chain in order to understand the role played by the different

Amino acids in protein structure and function, the more hydrophobic Leucine, Isoleucine, Valine, Tyrosine, (uncharged) and Proline,

In globular proteins the side chain R group from the more hydrophobic amino acid are folded into the interior of the protein molecule, away from the water salvation, Exception to the above rule may occur in small regions of the total protein molecule and are usually associate with a function of the protein such as providing a hydrophobic binding site for substrate or ligand molecules to the protein, Amino acids with intermediate polarity include the smaller alkyl amino acids, Glutamine, asparagines, threonine, serine, and methionine, these amino acids side chains are found both in the interior and on the solvent protein interface significant proportions, In contrast the amino acids containing charged R group at pH 7 [Lysine, arginine, Leucine (charged), Glutamate and aspartate] are most always found on surface in globular protein, where the charge is stabilized by the water solvent, the rare positioning of a charged side chain into the interior of globular protein is usually correlated with an essential structure or functional role for the buried charged side chain group within the non-polar interior of the protein,

LEUCINE

Regular Structure of the Common Amino Acids

----------COO-

----------|

----H3N – C – H Regular structure of common amino acids,

----------|

----------R

In the structure the ionized form for common amino acids that present in solution at 7.0 pH, is shown,

For example,

= a2 + b2 = c2

= a2 (NH3) + b2 (H) = c2

= a2 (17.75) + b2 (1.25) = c2

= a2 (315.0625) + b2 (1.5625) = c2

= a + b = 316.625 = c2

= a + b = 316.625 / 44 (COO-) = 7.19

= a + b = 7 = pH

LEUCINE

Regular + Biological Structure of the Leucine

Leucine + Human Chromosomes

= a2 + b2 = c2

= a2 (NH3) + b2 (chromosomes) = c2

= a2 (17.75) + b2 (46.25) = c2

= a2 (315.0625) + b2 (2139.0625) = c2

= a + b = 2454.125 = c2

= a + b = 2454.125 / 49.5 = 49.5

= a + b = 2454.125 + 28.25 (Alpha C + H13 = 28.25) = 2482.375

= a + b = 2482.375 / 49.82 = 49.82

= a + b = 49.82 + 6.1 pH = 55.92---------- Muscles pH 6.1

= a + b = 55.92 + 2.5 H2 = 58.42----- H2 for A//T base of DNA

= a + b = 58.42 + 4.955 (H4 = 5) = 63.375----- hydrophobic

= a + b = 63.375 + 3.75 H3 = 67.125----- H3 for G///C base of DNA

= a + b = 67.125 + 67.125 = 134.25

= a + b = 67.125 + R = 134.25

= a + b = 134.25 = Leucine (By hydrophobic)

Here Leucine = C + H13 = C6H13NO2

The role played by the different Amino acids in protein structure and function, the more hydrophobic Leucine, Isoleucine, Valine, Tyrosine, (uncharged) and Proline

Reaction of Leucine

= a2 / b1 = c2

= a2 Leucine / b1 chromosomes = c2

= a2 134.25 / b1 46.25 chromosomes = c2

= a2 18023.0625 / b1 46.25 = c2

= a / b = 389.68 = c2

= a / b = 390 / 6.1 pH of muscles = 63.93

= a / b = 63.93 + 0.32 (0.32) = 64.25

= a / b = 64.25 = Peptide

NH3 – C – COO-

Regular = C2H5NO2 = 64.25

Leucine = 134.25 mole grams

Regular = C2H5NO2 = 64.25

= a2 + b2 = c2

= a2 Regular + b2 chromosomes = c2

= a2 64.25 + b2 46.25 = c2

= a 4128.0625 + b 2139.0625 = c2

= a + b = 6267.125 = c2

= a + b = 6267.125 / 79.16 = 79.16

= a + b = 79.16 + 55.09 (2H2O = 55.5) = 134.25 Leucine

= a + b = 79.16 + 70.34 (2CH2OH + H6 = 71) = 149.5 Lysine

Enzymes number = 134.25

Enzymes number = 149.5

NH3 – C – COO-

R-2.326

Regular = R group = 2.326

Regular = 64.25 * 2.326 times = 149.44

Regular = 149.5 = C6H14N2O2 = Lysine (Charged)

Regular = 149.5 / 21.25 (H17 hydrophobic) = 7.0

Regular = pH 7.0

In contrast the amino acids containing charged R group at pH 7 [Lysine, arginine, histidine (charged), Glutamate and aspartate] are most always found on surface in globular protein

61 TO 92 YEAR AGE

61 to 92 year age = 65 heartbeat per minute

Regular = Leucine 134.25 + 149.5 Lysine = 283.75

= a2 + b2 = c2

= a2 Leucine + Lysine + b2 heartbeat = c2

= a2 283.75 + b2 65 = c2

= 80514.0625 + 4225 = c2

= a + b = 84739.0625 = c2

= a + b = 84739.0625 / 291.0 = 291.1

= 291.1 / 156.75 (Dipeptide) = 1.85

= 1.85 % (protein) in 61 to 92 year age,

31 TO 61 YEAR AGE