(Bio Mathematical Lab of Sikander Aqeel)
CHAPTER [3] PROTEINS
Proteins
(6/16/2016)
Polar and A-polar Proteins of the Amino acid R Group:
It is important to have an appreciation for the relative hydrophobicity of the amino acids side chain in order to understand the role played by the different
Amino acids in protein structure and function, the more hydrophobic Leucine, Isoleucine, Valine, Tyrosine, (uncharged) and Proline,
In globular proteins the side chain R group from the more hydrophobic amino acid are folded into the interior of the protein molecule, away from the water salvation, Exception to the above rule may occur in small regions of the total protein molecule and are usually associate with a function of the protein such as providing a hydrophobic binding site for substrate or ligand molecules to the protein, Amino acids with intermediate polarity include the smaller alkyl amino acids, Glutamine, asparagines, threonine, serine, and methionine, these amino acids side chains are found both in the interior and on the solvent protein interface significant proportions, In contrast the amino acids containing charged R group at pH 7 [Lysine, arginine, histidine (charged), Glutamate and aspartate] are most always found on surface in globular protein, where the charge is stabilized by the water solvent, the rare positioning of a charged side chain into the interior of globular protein is usually correlated with an essential structure or functional role for the buried charged side chain group within the non-polar interior of the protein,
ISOLEUCINE
Regular Structure of the Common Amino Acids
----------COO-
----------|
----H3N – C – H Regular structure of common amino acids,
----------|
----------R
In the structure the ionized form for common amino acids that present in solution at 7.0 pH, is shown,
For example,
= a2 + b2 = c2
= a2 (NH3) + b2 (H) = c2
= a2 (17.75) + b2 (1.25) = c2
= a2 (315.0625) + b2 (1.5625) = c2
= a + b = 316.625 = c2
= a + b = 316.625 / 44 (COO-) = 7.19
= a + b = 7 = pH
ISOLEUCINE
Regular + Hydrophobic Structure of the Isoleucine
= a2 + b2 = c2
= a2 (NH3) + b2 (H) = c2
= a2 (17.75) + b2 (1.25) = c2
= a2 (315.0625) + b2 (1.5625) = c2
= a + b = 316.625 = c2
= a + b = 316.625 / 17.7 = 17.7
= a + b = 17.7 + 28.25 (Alpha C + H13 = 28.25) = 45.95
= a + b = 45.95 + 21.175 (H17 = 21.25) = 67.125 [Isoleucine hydrophobic]
= a + b = 67.125 + 67.125 = 317.25
= a + b = 67.125 + R = 317.25
= a + b = 134.25 = [Isoleucine hydrophobic]
Here Isoleucine = C + H13 = C6H13NO2
The role played by the different Amino acids in protein structure and function, the more hydrophobic Leucine, Isoleucine, Valine, Tyrosine, (uncharged) and Proline
Reaction of Isoleucine
= a2 / b1 = c2
= a2 Isoleucine / b1 hydrophobic = c2
= a2 134.25 / b1 21.25 (H17) = c2
= a2 18023.0625 / b1 21.25 = c2
= a / b = 848.14 = c2
= a / b = 848 / 7 pH of water = 121.14
= a / b = 121 + 13.25 (CH = 13.25) = 134.25
= a / b = 134.25 = [Isoleucine hydrocarbon] with
H
|
NH3 – C – COO-
|
R1
Regular = C2H5NO2 = 64.25
Isoleucine = 134.25 mole grams
Regular = C2H5NO2 = 64.25
= a2 + b2 = c2
= a2 Isoleucine + b2 Regular = c2
= a2 134.25 + b2 64.25 = c2
= a 18023.0625 + b 4128.0625 = c2
= a + b = 22151.125 = c2
= a + b = 22151.125 / 148.83 = 148.83
Enzymes number = 148.83
Enzymes number = 149
H
|
NH3 – C – COO-
|
R-2.848
Regular = R group = 2.326
Regular = 64.25 * 2.848 times = 182.984
Regular = 183 = C6H12O6 = Glucose (Charged)
Regular = 183 / 21.25 (H17 hydrophobic) = 8.61
Regular = pH 8.61 = 6.1 pH of Muscles + 2.51 pH of soft drink
61 TO 92 YEAR AGE
61 to 92 year age = 65 heartbeat per minute
Regular = Isoleucine 134.25 + 183 Glucose = 317.25
= a2 + b2 = c2
= a2 Isoleucine + Glucose + b2 heartbeat = c2
= a2 317.25 + b2 65 = c2
= 100647.5625 + 4225 = c2
= 100647.5625 + 4225 = c2
= a + b = 104872.5625 = c2
= a + b = 104872.5625 / 323.84 = 323.84
= 323.84 / 134.25 (Isoleucine) = 2.41
= 323.84 / 183 (Glucose) = 1.76
= 3.9 % (Isoleucine + Glucose) in 61 to 92 year age,
31 TO 61 YEAR AGE
31 to 61 year age = 75 heartbeat per minute
Regular = Isoleucine 134.25 + 149.5 Glucose = 317.25
= a2 + b2 = c2
= a2 Isoleucine + Glucose + b2 heartbeat = c2
= a2 317.25 + b2 75 = c2
= 100647.5625 + 5625 = c2
= 100647.5625 + 5625 = c2
= a + b = 106272.5625 = c2
= a + b = 106272.5625 / 325.99 = 325.99
= 325.99 / 134.25 (Isoleucine) = 2.42
= 325.99 / 183 (Glucose) = 1.78
= 4.2 % (Isoleucine + Glucose) in 31 to 61 year age,
1 TO 31 YEAR AGE
1 to 31 year age = 120 heartbeat per minute
Regular = Isoleucine 134.25 + 149.5 Glucose = 317.25
= a2 + b2 = c2
= a2 Isoleucine + Glucose + b2 heartbeat = c2
= a2 317.25 + b2 120 = c2
= 100647.5625 + 14400 = c2
= 100647.5625 + 14400 = c2
= a + b = 115047.5625 = c2
= a + b = 115047.5625 / 339.18 = 339.19
= 339.19 / 134.25 (Isoleucine) = 2.52
= 339.19 / 183 (Glucose) = 1.85
= 4.37 % (Isoleucine + Glucose) in 1 to 31 year age,
The heart beating rate of one year child is 120 times per minute, and heartbeat increases quantity of amino acids into the cells,
3.9 % (Isoleucine + Glucose) will be called non process of protein
4.2 % (Isoleucine + Glucose) will be called low process of protein
4.37 % (Isoleucine + Glucose) will be called full process of protein
4.37 % (Isoleucine + uncharged) will be called full process of protein
4.37 % (Glucose + surface) will be called full process of protein
One of three important amino acids chain of (BCAA), which of requirment occurs in hemoglobin, and muscels tissues use Isoleucine glucose as energy sourses, and the BCAA levels are significantly decreased by insulin,
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