(Bio Mathematical Lab of Sikander Aqeel)
CHAPTER [3] PROTEINS
Proteins
(7/2/2016)
Polar and A-polar Proteins of the Amino acid R Group:
It is important to have an appreciation for the relative hydrophobicity of the amino acids side chain in order to understand the role played by the different
Amino acids in protein structure and function, the more hydrophobic Leucine, Isoleucine, Valine, Tyrosine, (uncharged) and Proline,
In globular proteins the side chain R group from the more hydrophobic amino acid are folded into the interior of the protein molecule, away from the water salvation, Exception to the above rule may occur in small regions of the total protein molecule and are usually associate with a function of the protein such as providing a hydrophobic binding site for substrate or ligand molecules to the protein, Amino acids with intermediate polarity include the smaller alkyl amino acids, Glutamine, asparagines, threonine, serine, and methionine, these amino acids side chains are found both in the interior and on the solvent protein interface significant proportions, In contrast the amino acids containing charged R group at pH 7 [Lysine, arginine, histidine (charged), Glutamate and aspartate] are most always found on surface in globular protein, where the charge is stabilized by the water solvent, the rare positioning of a charged side chain into the interior of globular protein is usually correlated with an essential structure or functional role for the buried charged side chain group within the non-polar interior of the protein,
GLUTAMATE
Regular Structure of the Common Amino Acids
----------COO-
----------|
----H3N – C – H Regular structure of common amino acids,
----------|
----------R
In the structure the ionized form for common amino acids that present in solution at 7.0 pH, is shown,
For example,
= a2 + b2 = c2
= a2 (NH3) + b2 (H) = c2
= a2 (17.75) + b2 (1.25) = c2
= a2 (315.0625) + b2 (1.5625) = c2
= a + b = 316.625 = c2
= a + b = 316.625 / 44 (COO-) = 7.19
= a + b = 7 = pH
GLUTAMATE
Regular + Hydrophobic Structure of the Glutamate
= a2 + b2 = c2
= a2 (NH3) + b2 (H) = c2
= a2 (17.75) + b2 (1.25) = c2
= a2 (315.0625) + b2 (1.5625) = c2
= a + b = 316.625 = c2
= a + b = 316.625 / 17.7 = 17.7
= a + b = 17.7 + 23.25 (Alpha C + H9 = 23.25) = 40.95
= a + b = 40.95 + 33.675 (O + H14 = 33.5) = 74.625 [Glutamate hydrophobic]
= a + b = 74.625 + 74.625 = 149.25
= a + b = 74.625 + R = 149.25
= a + b = 149.25 = [Glutamate hydrophobic]
Here Glutamate = C + H9 = C5H9NO4
In contrast the amino acids containing charged R group at pH 7 [Lysine, Arginine, Histidine (charged), Glutamate and aspartate] are most always found on surface in globular protein
Reaction of Glutamate
= a2 / b1 = c2
= a2 Glutamate / b1 hydrophobic = c2
= a2 149.25 / b1 33.675 (O + H14) = c2
= a2 22275.5625 / b1 37.675 = c2
= a / b = 591.25 = c2
= a / b = 591 / 7 pH of water = 84.42
= a / b = 84 + 65.25 (2CH2OH + H = 64.75) = 149.25
= a / b = 149.25 = [Glutamate hydrophobic Useful in treating anemia due to relationship to hemoglobin,
H
|
NH3 – C – COO-
|
R1
Regular = C2H5NO2 = 64.25
Glutamate = 149.25 mole grams
Regular = C2H5NO2 = 64.25
= a2 + b2 = c2
= a2 Glutamate + b2 Regular = c2
= a2 149.25 + b2 64.25 = c2
= a 22275.5625 + b 4128.0625 = c2
= a + b = 26403.625 = c2
= a + b = 26403.625 / 162.49 = 162.49
Enzymes number = 149.25
Enzymes number = 162.49 + 13.99 (N) = 148.5
H
|
NH3 – C – COO-
|
R-2.311
Regular = R group = 2.311
Regular = 64.25 * 2.311 times R = 148.48
Regular = 148.5 = C5H10N2O3 = Glutamine (alkyl amino acids)
Regular = 148.5 / 33.675 (O + H14) = 4.40
Regular = pH 4.40 = 4.3 pH of tomato juice
61 TO 92 YEAR AGE
61 to 92 year age = 65 heartbeat per minute
Regular = Glutamate 149.25 + 148.5 Glutamine = 297.75
= a2 + b2 = c2
= a2 Glutamate + Glutamine + b2 heartbeat = c2
= a2 297.75 + b2 65 = c2
= 88655.0625 + 4225 = c2
= 88655.0625 + 4225 = c2
= a + b = 92880.0625 = c2
= a + b = 92880.0625 / 304.76 = 304.76
= 304.76 / 149.25 (Glutamate) = 2.04
= 304.76 / 148.5 (Glutamine) = 2.05 +
= 4.09 % (Glutamate + (Glutamine) in 61 to 92 year age,
31 TO 61 YEAR AGE
31 to 61 year age = 75 heartbeat per minute
Regular = Glutamate 149.25 + 148.5 Glutamine = 297.75
= a2 + b2 = c2
= a2 Glutamate + Glutamine + b2 heartbeat = c2
= a2 297.75 + b2 75 = c2
= 88655.0625 + 5625 = c2
= 88655.0625 + 5625 = c2
= a + b = 94280.0625 = c2
= a + b = 94280.0625 / 307.05 = 307.05
= 307.05 / 149.25 (Glutamate) = 2.05
= 307.05 / 148.5 (Glutamine) = 2.06 +
= 4.11 % (Glutamate + (Glutamine) in 31 to 61 year age,
1 TO 31 YEAR AGE
1 to 31 year age = 120 heartbeat per minute
Regular = Glutamate 149.25 + 148.5 Glutamine = 297.75
= a2 + b2 = c2
= a2 Glutamate + Glutamine + b2 heartbeat = c2
= a2 297.75 + b2 120 = c2
= 88655.0625 + 14400 = c2
= 88655.0625 + 14400 = c2
= a + b = 103055.0625 = c2
= a + b = 103055.0625 / 321.02 = 321.02
= 321.02 / 149.25 (Glutamate) = 2.15
= 321.02 / 148.5 (Glutamine) = 2.16 +
= 4.31 % (Glutamate + (Glutamine) in 1 to 31 year age,
The heart beating rate of one year child is 120 times per minute, and heartbeat increases quantity of amino acids into the cells,
4.09 % (Glutamate + Glutamine) will be called non process of protein
4.11 % (Glutamate + Glutamine) will be called low process of protein
4.31 % (Glutamate + Glutamine) will be called full process of protein
4.28 % (Glutamate + Glutamine) will be called full process of protein
4.28 % (Glutamate + alkyl amino acids) will be called full process of protein,
Detoxifies ammonia in the brain by forming glutamine, which can cross the blood-brain barrier, which Glutamic Acid cannot do,
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