THE JAUNDICE AND ARGININE,

(Two Polynucleotide in mathematical machine of Sikander Aqeel) 

WILSON DISEASE 

Lower-than-normal ALP levels 

• 1 = Hypophosphatasia 

• 2 = Malnutrition 

• 3 = Wilson disease 

•

• Wilson disease has a range of clinical manifestations, from an asymptomatic state to fulminate hepatic failure, chronic liver disease with or without cirrhosis, neurologic, and psychiatric manifestations

• Consider hepatic Wilson disease in the differential diagnosis of any unexplained chronic liver disease, especially in individuals younger than 40 years. The condition may also manifest as acute hepatitis. Hepatic dysfunction is the presenting feature in more than half of patients. The 3 major patterns of hepatic involvement are as follows: 

• (1) chronic active hepatitis, 

• (2) cirrhosis, and 

• (3) fulminant hepatic failure. The most common initial presentation is cirrhosis. 

2 = CIRRHOSIS (8/12/2016) 

• Definitions of cirrhosis

• noun

• A chronic disease of the liver marked by degeneration of cells, inflammation, and fibrous thickening of tissue. It is typically a result of alcoholism or hepatitis.

• Chronic viral hepatitis is the main cause of chronic liver disease, cirrhosis and hepatocellular carcinoma throughout the world.

Symptoms caused by ac**ulations in liver or kidneys include:

• hypoglycemia

• kidney dysfunction

• jaundice (caused by liver failure)

• cirrhosis of the liver 

Alcoholism = affect of alcohol on human system = -OH single = 17.25 

Urease enzyme + Arginase enzyme = liver function        

Urease enzyme = liver = Urea = 7.0 optimum pH

Arginase enzyme = liver = Arginine substreat = 9.7 optimum pH 

Arginine = C6H14N4O2 = 177.5 m/g 

         = a2 + b2 = c2 

         = a2 Arginine + b2 Urease plus Arginase enzyme = c2  

         = a2 177.5 + b2 16.7 = c2 

         = a2 31506.25 + b2 278.89 = c2 

         = a + b = 31785.14 = c2     

         = a + b = 31785.14 / 178.28 = 178.28 

         = a + b = 178.28 / 2.5 (H2= A//T DNA) = 71.312 

         = a + b = 71.312 / 1.114 % copper in liver = 64.01 

         = a + b = 64.01 = Cu = Copper of liver  

MENKEN’S SYNDROME 

         It certainly hereditary disease, where copper does not active in whole body, and liver also does not gather normal quantity of copper, where diseases rise-up like brain disorders, reduction of hair, cold body, plasma, and liver, for Anemia, less proteins, less quantity of red cells in blood, 

Such as liver becomes fail from jaundice, from reason of reduction of copper in liver, 

Arginine = 177.5 * 7.0 Enzyme optimum pH = 1242.5 

         = 1242.5 * 9.7 Enzyme optimum pH = 12052.25 

         = 12052.25 / 64 Cu = 188.31640625 

         = 188.31 - 5.31 = 183 sugar of liver 

         = 183 = C6H12O6 sugar from reason of Insulin, if insulin is not present, then sugar will not,  

So if we do less optimum pH of liver enzymes, then sugar gathering system will be failed in liver, 

ABOUT CHOLESTASIS (8/14/2016) 

Cholestasis means any condition in which bile flow is reduced or stopped. "Chole" refers to bile and "stasis" means "not moving." Bile flow may be blocked inside the liver, outside the liver, or in both places. Symptoms may include:

• Jaundice

• Dark urine

• Pale stool

• Easy bleeding

• Itching

• Ascites 

• Chills

• Pain from the biliary tract or pancreas

• Enlarged gallbladder

Some causes of cholestasis include the following:

• Hepatitis

• Alcoholic liver disease

• Primary biliary cirrhosis

• Drug effects

• Hormonal changes during pregnancy

• A stone in the bile duct

• Bile duct narrowing

• Bile duct cancer

• Pancreatic cancer

• Inflammation of the pancreas 

JAUNDICE 

The non-Jaundice health depend on high Arginine, and less Arginine in blood causes of jaundice disease,     

Arginine = C6H14N4O2 = 177.5 m/g 

Arginine = 177.5 / 100 % = 1.775

         = 2.935 * 60.47 % = 177.47

         = 177.47 m/g = 60.47 percent Arginine

Urease enzyme = liver = Urea = 7.0 optimum pH

Arginase enzyme = liver = Arginine substreat = 9.7 optimum pH 

Urease + Arginase enzyme = 16.7 optimum pH   

60.47 % Arginine = 177.47 m/g

         = a2 + b2 = c2 

         = a2 60.47 % Arginine + b2 Urease plus Arginase enzyme = c2  

         = a2 177.47 + b2 16.7 = c2 

         = a2 31495.6009 + b2 278.89 = c2 

         = a + b = 31774.4909 = c2     

         = a + b = 31774.4909 / 178.25 = 178.25

         = a + b = 178.25 / 2.5 (H2= A//T DNA) = 71.3

         = a + b = 71.3 / 3.75 (H3= C///G DNA) = 19.01

         = a + b = 19 * 50 ratio = 950

         = a + b = 950 / 30.82A = 30.82A

         = a + b = 31A = healthy height of helix  

        = Arginine = 31A / 10 mononucleotide = 3.1

        =          = 3.1A healthy distance between two base pair, 

So the 60.47 percent Arginine doing small or short to helix of DNA, and doing less to hemoglobin in blood to rise up yellow color of jaundice, 

For example 

Urease enzyme = liver = Urea = 7.0 optimum pH

Arginase enzyme = liver = Arginine substreat = 9.7 optimum pH  

Urease + Arginase enzyme = 16.7 optimum pH   

60.47 % Arginine = 177.47 m/g

         = a2 + b2 = c2 

         = a2 60.47 % Arginine + b2 Urease plus Arginase enzyme = c2  

         = a2 177.47 + b2 16.7 = c2 

         = a2 31495.6009 + b2 278.89 = c2 

         = a + b = 31774.4909 = c2     

         = a + b = 31774.4909 * 2.029 pepsin optimum pH of various enzyme = 64470.44 

         = a + b = 64470.44 + 29.56 = 64500 

         = a + b = 64500 molecular weight of hemoglobin, 

Now various enzymes started to be build in stomach for jaundice,