Sikander Aqeel

THE ALCOHOLIC LIVER DISEASE,

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(Two Polynucleotide in mathematical machine of Sikander Aqeel) 

WILSON DISEASE 

Lower-than-normal ALP levels 

1 = Hypophosphatasia 

2 = Malnutrition 

3 = Wilson disease 

Wilson disease has a range of clinical manifestations, from an asymptomatic state to fulminate hepatic failure, chronic liver disease with or without cirrhosis, neurologic, and psychiatric manifestations

Consider hepatic Wilson disease in the differential diagnosis of any unexplained chronic liver disease, especially in individuals younger than 40 years. The condition may also manifest as acute hepatitis. Hepatic dysfunction is the presenting feature in more than half of patients. The 3 major patterns of hepatic involvement are as follows: 

(1) chronic active hepatitis, 

(2) cirrhosis, and 

(3) fulminant hepatic failure. The most common initial presentation is cirrhosis. 

 

2 = CIRRHOSIS (8/12/2016) 

Definitions of cirrhosis

noun

A chronic disease of the liver marked by degeneration of cells, inflammation, and fibrous thickening of tissue. It is typically a result of alcoholism or hepatitis.

Chronic viral hepatitis is the main cause of chronic liver disease, cirrhosis and hepatocellular carcinoma throughout the world.

 

ABOUT CHOLESTASIS (8/23/2016) 

Cholestasis means any condition in which bile flow is reduced or stopped. "Chole" refers to bile and "stasis" means "not moving." Bile flow may be blocked inside the liver, outside the liver, or in both places. Symptoms may include:

Jaundice

Dark urine

Pale stool

Easy bleeding

Itching

Ascites 

Chills

Pain from the biliary tract or pancreas

Enlarged gallbladder

Some causes of cholestasis include the following:

Hepatitis

Alcoholic liver disease

Primary biliary cirrhosis

Drug effects

Hormonal changes during pregnancy

A stone in the bile duct

Bile duct narrowing

Bile duct cancer

Pancreatic cancer

Inflammation of the pancreas 

 

ALCOHOLIC LIVER DISEASE 

TERTIARY NATURAL ALCOHOL

The Alcoholic liver disease with Urease and Arginase enzymes of liver, while Tertiary natural Alcohol being use for disease,       

 

Tertiary Alcohol = C4-OH = 65.25 m/g 

Tertiary Alcohol = 65.25 / 100 % = 0.6525

                 = 0.6525 * 436.78 % = 285

                 = 285 m/g = 436.78 percent  Alcohol

 

 

Urease enzyme = Liver = 8.0 optimum pH = (substrate = Urea)

Arginase enzyme = Liver = 9.7 optimum pH = (substrate = Arginine amino acids) 

 

Urease + Arginase enzyme = 17.7 optimum pH   

436.78 % Alcohol = 285 m/g

 

         = a2 + b2 = c2 

         = a2 (436.78 % Alcohol) + b2 (Urease + Arginase enzyme) = c2  

 

         = a2 285 + b2 17.7 = c2 

 

         = a2 81225 + b2 313.29 = c2 

 

         = a + b = 81538.29 = c2     

         = a + b = 81538.29 / 285.54 = 285.55

 

         = a + b = 285.55 / 2.5 (H2= A//T DNA) = 114.22

         = a + b = 114.22 / 3.75 (H3= C///G DNA) = 30.45

         = a + b = 30.45 * 50 ratio = 1522.5 

         = a + b = 1522.5 / 39.03A = 39A

         = a + b = 39A = healthy height of helix  

 

        = Alcohol = 39A / 10 mononucleotide = 3.9

        =         = 3.9A healthy distance between two base pair, 

 

Large helix of DNA from over alcohol in blood, 

 

For example 

Urease enzyme = Liver = 8.0 optimum pH = (substrate = Urea)

Arginase enzyme = Liver = 9.7 optimum pH = (substrate = Arginine amino acids) 

 

Urease + Arginase enzyme = 17.7 optimum pH   

436.78 % Alcohol = 285 m/g

 

    = a2 + b2 = c2 

    = a2 (436.78 %  Alcohol) + b2(Urease + Arginase enzyme) = c2  

 

    = a2 285 + b2 17.7 = c2 

 

    = a2 81225 + b2 313.29 = c2 

 

    = a + b = 81538.29 = c2     

    = a + b = 81538.29 – 64500 m/g hemoglobin = 17038.29 

    = a + b = 17038.29 = toxic substances building up in the blood 

 

 

Diseases Liver enlargement

    = a + b = 17038.29 / 9.7 pH of arginsea enzymes of liver = 1756.52 

    = a + b = 1756.52 / 7.0 pH of Urease enzymes of Urea = 250.93 

    = a + b = 251 / 8.0 pH of Lipase enzymes of pancreas = 31.375 

    = a + b = 31.375 + 0.375 = 31.75 

    = a + b = 31.75 = CH2OH = fructose, 

 

So 39A height of helix and 3.9A distance of base pair are increasing of liver, Urea, and pancreas diseases, while Liver enlargement disease is continuous, 

 

Liver enlargement is usually an indicator of liver disease, although there are usually no symptoms associated with a slightly enlarged liver (hepatomegaly). Symptoms of a grossly enlarged liver include abdominal discomfort or "feeling full."

After enlargement of liver the Liver encephalopathy diseases rise-up, such as changes of logical thinking, personality, and behavior, 

 

Liver encephalopathy is the deterioration of brain function and damage to the nervous system due to toxic substances building up in the blood, which are normally removed by the liver. Liver encephalopathy is also called portal-systemic encephalopathy, hepatic encephalopathy, or hepatic coma. Symptoms may include:

Impaired consciousness

Changes in logical thinking, personality, and behavior

Mood changes

Impaired judgment

Drowsiness

Confusion

Sluggish speech and movement

Disorientation

Loss of consciousness

Coma

Seizures (rare)

Muscle stiffness or tremors

Uncontrollable movement 

 

Tertiary Alcohol = 331.08 % for healthy functions 

Increased Alcohol = 105.7 % for Liver encephalopathy  

    Total Alcohol = 436.78 = 39A and 3.9A = damage to the nervous system due to toxic substances building up in the blood, and it is naturally by increment of natural alcohol, 

For example! You took 105.7 % extra alcohol through the medicines, then Liver encephalopathy disease rise-up with Changes in logical thinking, personality, and behavior, from reason of large helix of DNA 39A and 3.9A,    

 

 

ALP - BLOOD TEST        

Normal Results (ALP) tissues protein

The normal range is 44 to 147 IU/L (international units per liter) 

 

The normal range = 147 IU/L for maximum weight and young age    

The normal range = 44 IU/L for minimum weight and over age  

 

HEALTHY LIVER

OVER ALCOHOL IN ALP BLOOD TEST (LOWER) 

(ALP) tissues protein = 44 * 6.47 (pH of small intestine) = 284.68

                      = 285 m/g = 436.78 % over Alcohol, 

 

LIVERE  

OVER ALCOHOL IN ALP BLOOD TEST (HIGHER) 

(ALP) tissues protein = 147 * 1.938 (pepsine optimum pH) = 284.886

                      = 285 m/g = 436.78 % over Alcohol,  

 

 

 

 

 

 

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