BRIGHT FUTURE OF MEMBRANE

(Bright Future of Membrane in cosmos of Sikander Aqeel)

The Membrane thickness which has important attention about gathering of chemical compounds, the heavy membrane gathers heavy value of lipids, proteins and carbohydrate, or lipids protein carbohydrate + membrane thickness = 212, or 112 is an basic structure of membrane and 100 % chemicals are equal to lipids protein carbohydrate of membrane, or 112 % thick membrane can catch to 100 % thick lipids protein carbohydrate, if membrane is 50 % thick, then 50 % thick membrane will catch to 56 % lipids protein carbohydrate,           

It is important to treatment of too over age, supposed you giving lipids protein carbohydrate through the medicines to patient for good health, but there are not effect on medicines, because there membrane is 25 % thick in too over age, they cannot catch to heavy lipids protein carbohydrate, so here in too over age need is health or treatment of thickness of membrane,  

IN HEALTH, 

Thickness of membrane = 112 % large type + Lipids protein carbohydrate 100 % large type = 212 % healthy membrane 

Or 112 % large type + 100 % large types = 212 % balance between chemicals and membrane thickness 

IN DISEASE  

Thickness of membrane = 25 % large type + Lipids protein carbohydrate 100 % large type = 125 % sick membrane 

Or 25 % large type + 100 % large types = 125 % unbalance between chemicals and membrane thickness 

So form of basic membrane and form of Lipids protein carbohydrate are two different forms,   

If first we will treat of thickness of membrane, then thick membrane will automatically catch to healthy Lipids protein carbohydrate in over age,    

Cell Membrane 

Cell Membrane = 40 % lipids + 40 % thick Membrane at fatty acid = 80 

Cell Membrane = 55 % protein + 55 % thick Membrane at amino acid side = 110 

Cell Membrane = 5 % carbohydrate + 17 % thick Membrane at carbon side = 22 

                                                                Total = 212 Membrane 

Cell Membrane compounds = 100 % 

Cell Membrane thickness = 112 % 

Total Membrane = 212

         = a2 + b2 = DNA helix

         = a2 46 Chromosomes  + b2 212 Membrane = c2  

         = a2 46 + b2 212 = c2 

         = a2 2116 + b2 44944 = c2 

         = a + b = 47060 = c2     

         = a + b = 47060 / 216.93 = 216.93

         = a + b = 216.93 / 2.5 (H2= A//T DNA) = 86.772

         = a + b = 86.772 / 3.75 (H3= C///G DNA) = 23.1392

         = a + b = 23.1392 * 50 ratio = 1156.96

         = a + b = 1157 / 34.01A = 34.01A

         = a + b = 34A = healthy height of helix  

        = DNA helix = 34A / 10 mononucleotide = 3.4

        =           = 3.4A healthy distance between two base pair, 

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DEPENDENCE OF MEMBRANE (8/26/2016)

HYDROPHILIC HEAD AND HYDROPHOBIC TWO TAILS

1 = hydrophilic head = PO4 + CH2 + C2H2O2 = phosphate group + Glycerol,  

While Glycerol is a sweet syrupy trihdroxy alcohol obtained by saponification of fats and oils 

2 = hydrophobic two tail = saturated fatty acid + unsaturated fatty acid 

The membrane wall depend on micro-organisms of head and two tails, which of food chain occurs phospholipids + Glycerol + fatty acid, and this three compounds and water make healthy and strong to membrane wall, 

When membrane wall become sick or ill in over age, then they occurs not able to eat or absorb phospholipids + Glycerol + fatty acid in wall, and from this reasons the body bio functions becomes damage to make healthy body, if we repair to wall of membrane then may restart process of bio-health in body, 

Because healthy cell membrane wall = proteins transport = childhood 

And unhealthy cell membrane wall = zero transport of proteins = over age 

CELL MEMBRANE OF OVER AGE 

THIN MEMBRANE WITH SICK HEAD OF  

Cell Membrane = 10 % lipids + 10 % thick Membrane at fatty acid = 20 

Cell Membrane = 13.75 % protein + 13.75 % thick Membrane at amino acid side = 27.5 

Cell Membrane = 1 % carbohydrate + 8 % thick Membrane at carbon side = 9 

                                                                Total = 56.5 Membrane of over age 

Cell Membrane compounds = 24.75 % 

Cell Membrane thickness = 31.75 % 

Total Membrane = 56.5 

Total over age Membrane = 56.5 

Phosphate = 95 m/g

         = a2 + b2 = DNA helix

         = a2 Phosphate + b2 over Membrane = c2  

         = a2 95 + b2 56.5 = c2 

         = a2 9025 + b2 3192.25 = c2 

         = a + b = 12217.25 = c2     

         = a + b = 12217.25 / 110.53 = 110.53

         = a + b = 110.53 / 2.5 (H2= A//T DNA) = 44.212

         = a + b = 44.212 / 3.75 (H3= C///G DNA) = 11.78

         = a + b = 11.78 * 50 ratio = 589

         = a + b = 589 / 24.26A = 24.27A

         = a + b = 24A = less phosphate type height of helix  

        = DNA helix = 24A / 10 mononucleotide = 2.4

        =           = 2.4A less phosphate type distance between two base pair, 

Less phosphate type distance between two base pair = 2.4A – 0.1 % proteins = 2.3A unhealthy distance between two base pair, 

So phosphate 95 m/g = 0.1 % phosphate happening use only in membrane, and phosphate are not going into the cell for energy, because the DNA helix already weak or sick from over age, 

Basically in over age, the phosphate need occurs too much, because first membrane fills own self from phosphate and supply into the cell later, or in easy words, 

Less phosphate type distance between two base pair = 2.4A + 1 % phosphate = 3.4A healthy distance between two base pair, 

So the over age belongs with need of 1 % phosphate, while 0.1 % phosphate is equal to 95, PO4, m/g phosphate, so 1 % / 0.1 % = 10 times less phosphate in over age, 

therefore 95 * 10 = 950 m/g too much phosphate need in over age for healthy membrane, and this recovery of phosphate is too much hard but not impossible, 

MYRISTIC ACID (8/26/2016) 

Although the phosphate used in many portion of cell, but most important the phosphate and phosphate-lipids divides in cell’s water, nucleic membrane, cell membrane, and helix of DNA, if hydrophilic head is strong and filled with phosphate, naturally if hydrophilic head is not proper filled with phosphate, then hydrophilic head will not supply to phosphate into the cell’s water, nucleic membrane, cell membrane, and helix of DNA, 

THE PHOSPHATIDYLINOSITOL, 

The phosphate groups are also found on C-4 or C-5 of the inositol, the additional phosphate groups increase the charge of the hydrophilic head or polar head of this Phosphatidylinositol, 

So if charge increased of phosphate in hydrophilic head then membrane will be active to gather in polar head and transport protein into the cell, 

So we are using Myristic acid in too weak membrane, for increase charge of polar head, 

CHEMICAL COMPOSITION OF MEMBRANE 

Lipids and proteins are the two important components of all membranes but the present of each varies greatly between different membrane of protein ranges from about 20 % in the myelin sheath to over 70 % in the inner membrane of the mitochondria, intracellular membranes have a high percent of protein presumably because of the greater enzymatic activity of these membranes membrane also contain on a small percent of various polysaccharides in the form of glycoprotein and glycol-lipid there is no free carbohydrate in membrane, 

CHEMICAL COMPOSITION OF MEMBRANE

The three important lipid component of membrane are phosphoglycrides sphingolipids, and cholesterol individual cellular membranes also contain on small quantities of other lipids, such as triacylglycerol and diol derivative, but their function are uncertain the percentage of the important classes varies significantly in different membranes, and is presumably related to the specific role of phosphoglycerides 

FATTY ACIDS IN PHOSPHOGLYCERIDES

CELL MEMBRANE OF OVER AGE 

THIN MEMBRANE WITH SICK HYDROPHILIC HEAD    

Cell Membrane = 10 % lipids + 10 % thick Membrane at fatty acid = 20 

Cell Membrane = 13.75 % protein + 13.75 % thick Membrane at amino acid side = 27.5 

Cell Membrane = 1 % carbohydrate + 8 % thick Membrane at carbon side = 9 

                                                                Total = 56.5 Membrane of over age 

Cell Membrane compounds = 24.75 % 

Cell Membrane thickness = 31.75 % 

Total Membrane = 56.5 

Total over age Membrane = 56.5 

Myristic acid = n-Tetradecanoic = CH3 - (CH2)12 - COOH = 235

         = a2 + b2 = DNA helix

         = a2 Myristic acid + b2 over Membrane = c2  

         = a2 235 + b2 56.5 = c2 

         = a2 55225 + b2 3192.25 = c2 

         = a + b = 58417.25 = c2     

         = a + b = 58417.25 / 241.69 = 241.70

         = a + b = 241.70 / 2.5 (H2= A//T DNA) = 96.68

         = a + b = 96.68 / 3.75 (H3= C///G DNA) = 25.78

         = a + b = 25.78 * 50 ratio = 1289

         = a + b = 1289 / 35.90A = 35.90A

         = a + b = 36A = Myristic acid type height of helix  

        = DNA helix = 36A / 10 mononucleotide = 3.6

        =           = 3.6A Myristic acid type distance between two base pair, 

3.6A Myristic acid type distance between two base pair = 3.6A – 0.2 % transport of proteins = 3.4A height of natural helix, from 26-carbon of Myristic acid,  

If you are not fresh and strong in over age that yours membrane is empty from Myristic acid for increase charge of hydrophilic head with the health, because answer 0.2 % protein transporting into the cell, or 0.1 % for outer head and 0.1 % for inner head, 

MYRISTIC ACID

Nutmeg **er has 75% trimyristin, the triglyceride of myristic acid. Besides nutmeg, myristic acid is also found in palm kernel oil, coconut oil, **er fat and is a minor component of many other animal fats.[9] It is also found in **aceti, the crystallized fraction of oil from the ** whale. It is also found in the rhizomes of the Iris, including Orris root, 

Myristic acid is commonly added co-translationally to the penultimate, nitrogen-terminus, glycine in receptor-associated kinases to confer the membrane localisation of the enzyme, The myristic acid has a sufficiently high hydrophobicity to become incorporated into the fatty acyl core of the phospholipid bilayer of the plasma membrane of the eukaryotic cell. In this way, myristic acid acts as a lipid anchor in biomembranes, 

The ester isopropyl myristate is used in cosmetic and topical medicinal preparations where good absorption through the skin is desired,

Reduction of myristic acid yields myristyl aldehyde and myristyl alcohol.