THE BILE DUCT CANCER,

(Two Polynucleotide in mathematical machine of Sikander Aqeel) 

WILSON DISEASE 

Lower-than-normal ALP levels 

1 = Hypophosphatasia 

2 = Malnutrition 

3 = Wilson disease 

Wilson disease has a range of clinical manifestations, from an asymptomatic state to fulminate hepatic failure, chronic liver disease with or without cirrhosis, neurologic, and psychiatric manifestations

Consider hepatic Wilson disease in the differential diagnosis of any unexplained chronic liver disease, especially in individuals younger than 40 years. The condition may also manifest as acute hepatitis. Hepatic dysfunction is the presenting feature in more than half of patients. The 3 major patterns of hepatic involvement are as follows: 

(1) chronic active hepatitis, 

(2) cirrhosis, and 

(3) fulminant hepatic failure. The most common initial presentation is cirrhosis. 

= CIRRHOSIS  

Definitions of cirrhosis

noun

A chronic disease of the liver marked by degeneration of cells, inflammation, and fibrous thickening of tissue. It is typically a result of alcoholism or hepatitis.

Chronic viral hepatitis is the main cause of chronic liver disease, cirrhosis and hepatocellular carcinoma throughout the world.

ABOUT CHOLESTASIS (9/11/2016) 

Cholestasis means any condition in which bile flow is reduced or stopped. "Chole" refers to bile and "stasis" means "not moving." Bile flow may be blocked inside the liver, outside the liver, or in both places. Symptoms may include:

Jaundice

Dark urine

Pale stool

Easy bleeding

Itching

Ascites 

Chills

Pain from the biliary tract or pancreas

Enlarged gallbladder

Some causes of cholestasis include the following:

Hepatitis

Alcoholic liver disease

Primary biliary cirrhosis

Drug effects

Hormonal changes during pregnancy

A stone in the bile duct

Bile duct narrowing

Bile duct cancer

Pancreatic cancer

Inflammation of the pancreas 

BILE DUCT CANCER (9/11/2016 

The Bile duct with normal or healthy natural helix of DNA 

Blood plasma = 7.4 pH 

Urine = 4.6 to 8.0 pH  

Healthy Helix height = 34A 

Healthy Helix distance between two base pair = 3.4A   

         = a2 + b2 = c2 

         = a2 (helix height) + b2 (helix distance two base) = c2  

         = a2 34A + b2 3.4A = c2 

         = a2 1156 + b2 11.56 = c2 

         = a + b = 1167.56 = c2     

         = a + b = 1167.56 / 34.34 = 34.34

         = a + b = 34.34 * 2.5 (H2= A//T DNA) = 85.85

         = a + b = 85.85 * 3.75 (H3= C///G DNA) = 321.9375

         = a + b = 321.9375 * 50 ratio = 16096.875  

         = a + b = 16096.875 / 458 (amino acids of alpha-globulin) = 35.14

         = a + b = 35 / 7.4 pH (blood plasma) = 4.72

         = a + b = 4.6 to 8.0 pH of urine.  

The alpha-globulin protein has been tested for use as a cancer treatment that would activate macrophages against cancer cells, 

Vitamin D-binding protein belongs to the albumin gene family, together with human serum albumin and alpha-fetoprotein. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues, As Gc protein-derived macrophage activating factor it is a Macrophage Activating Factor (MAF) that has been tested for use as a cancer treatment that would activate macrophages against cancer cells, 

ALP - blood test

Alkaline phosphatase (ALP) is a protein found in all body tissues. Tissues with higher amounts of ALP include the liver, bile ducts, and bone.

A blood test can be done to measure the level of ALP.

A related test is the ALP isoenzyme test. 

Phosphorus blood test

What Abnormal Results Mean

A higher than normal level (hyperphosphatemia) may be due to many different health conditions. Common causes include:

Diabetic ketoacidosis (life-threatening condition that may occur in people with diabetes)

Hypoparathyroidism (parathyroid glands do not make enough of their hormone)

Kidney failure

Liver disease

Too much vitamin D

Too much phosphate in your diet

Use of certain medicines such as laxatives that have phosphate in them

A lower than normal level (hypophosphatemia) may be due to:

Alcoholism,  

BILE DUCT CANCER 

The Bile duct with normal or healthy natural helix of DNA 

Blood plasma = 7.4 pH 

Urine = 4.6 to 8.0 pH  

Healthy Helix height = 34A 

Healthy Helix distance between two base pair = 3.4A   

         = a2 + b2 = c2 

         = a2 (helix height) + b2 (helix distance two base) = c2  

         = a2 34A + b2 3.4A = c2 

         = a2 1156 + b2 11.56 = c2 

         = a + b = 1167.56 = c2     

         = a + b = 1167.56 / 34.34 = 34.34

         = a + b = 34.34 * 2.5 (H2= A//T DNA) = 85.85

         = a + b = 85.85 * 3.75 (H3= C///G DNA) = 321.9375

         = a + b = 321.9375 * 50 ratio = 16096.875  

         = a + b = 16096.875 / 80 % (organic compounds) = 201.2109375

         = a + b = 201.21 / 6.2 pH (Sucrose enzyme of small intestine) = 32.45

         = a + b = 33 / 8 pH (Trypsin enzyme of small intestine) = 4.125

         = a + b = 4.125 pH of lipase enzymes of stomach,   

The main function of bile acids is to allow digestion of dietary fats and oils by acting as a surfactant that emulsifies them into micelles, allowing them to be colloid-ally suspended in thechyme before further processing. They also have hormonal actions throughout the body, particularly through the farnesoid X receptor and GPBAR1 (also known as TGR5) 

         = a + b = 16096.875 / 7.4 pH (blood plasma) = 2175.25

         = a + b = 2175 / 1.5 pH (pepsin enzyme) = 1450

         = a + b = 1450 / 38.07A = 38.08A 

         = a + b = 38A = height of helix from reason of hot stomach, 

COLORS BY WAVELENGTH FOR STOMACH 

= a + b = 1450 / 38.07A = 38.08A 

Then 1450 / 2A = 725 

Now 725 = 38A 

Now 725 = 38A

Therefore wave length = 725 (nm) = red + cyan = brown wavelength color 

Then brown color = hot stomach  

WAVELENGTH COLOR FOR BILE DUCT (9/16/2016)

= a + b = 1450 / 38.07A = 38.08A 

= a + b = 1450 / 1.25 H1 = 1160 

Then 1160 / 2A = 580 

Now 580 = 34.05A 

Now 580 = 34.06A normal height of helix 

Wavelength 570–585 = yellow color + blue complementary colors 

100 % yellow + 100 % blue complementary = dark green  

(9/18/2016)

Now 580 nm = dark green 

Now 145 nm = 25 % green  

Wavelength = 145 (nm) = 25 % green

Then green color = Bile duct,  

         = a2 + b2 = Cancer 

         = a2 (25 % green bile duct) + b2 (Glucose) = c2  

         = a2 145 (nm) + 1256 (C6H12O6) 6.86 = c2 

         = a2 21025 + b2 1577536 = c2 

         = a + b = 1598561 = ->Nucleic acid<- 

         = a + b = 1598561 = c2     

         = a + b = 1598561 / 1264.34 = 1264.34

         = a + b = 1264.34 / 20.392 (H2O + H) = 62

         = a + b = 62 = ->P2<-  

         = a + b = 1264.34 = ->Amino acids<-  

         = a + b = 1598561 / 1264.34 = 1264.34

         A

         = a + b = 1264.34 / 158 (amino acid) = 8.00

         = a + b = 8 pH of lipid (ester bond) from lipase enzyme of pancreas, 

         = a + b = 8 * 6.625 (E6.6) = 53 proteins

So the 25 % green color of bile duct is not infected with cancer, 

Now 145 nm = 25 % green color = 1256 (C6H12O6) 6.86 = glucose in bile fluid 

Now 145 nm = E6.6 = 53 proteins 

Now the much glucose doing weak to salt of bile fluid or Sodium bicarbonate, Sodium glycol cholate and sodium taurocholate salt, and the weak salted of bile duct becomes injured in shape of pimple of cancer from the too much glucose in bile duct cells, now 7 or 6.86 unit of glucose will produce bacteria and virus into the pimple of bile duct for cancer, 

And it is second last stage of disease from reason of lipid ester bond from the lipase enzyme of pancreas, and after 8 pH the cancer will rise-up with pain, and lipid, bacteria, and virus,  

The family also contains L-lactate dehydrogenases that catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis, while ADP and ATP as energy will develop tumor M2-PK from glycolysis for pyruvate to lactate,      

Basically the dark green color is a kind of strong acids, and light green color is a kind of weak and sick acids, such as  

Colors of ions in aqueous solution

1 =  Manganate (VI) = MnO2−4 = Dark green = (- radical)    

2 = Iron (III) = Fe3+ = Very pale violet/brown = (+ radical)      

In bacteria, a form of pyruvate dehydrogenase (also called pyruvate oxidase, EC 1.2.2.2) exists that links the oxidation of pyruvate into acetate and carbon dioxide to the reduction of ferrocytochrome. In E. coli this enzyme is encoded by the pox B gene and the protein has a flavin cofactor, this enzyme increases the efficiency of growth of E. coli under aerobic conditions, 

The E6 protein consists of 158 amino acid residues and contains two zinc-finger binding motifs (2). The E6 protein is thought to promote cell proliferation by stimulating degradation of the tumor suppressor p53 protein via the formation of a trimeric complex comprising E6, p53 and the cellular ubiquitination enzyme E6-AP. 

E6-stimulated degradation interferes with such biological functions of p53; thus perturbing the control of cell cycle progression, leading finally to increased tumor cell growth (3). Although it is commonly accepted that the ability of high-risk type HPV E6 to target p53 for degradation contributes to virus-induced cellular transformation, it is also clear that the E6 protein has ontogeny activities that are independent of p53.