(Two Polynucleotide in mathematical machine of Sikander Aqeel)
WILSON DISEASE
Lower-than-normal ALP levels
1 = Hypophosphatasia
2 = Malnutrition
3 = Wilson disease
Wilson disease has a range of clinical manifestations, from an asymptomatic state to fulminate hepatic failure, chronic liver disease with or without cirrhosis, neurologic, and psychiatric manifestations
Consider hepatic Wilson disease in the differential diagnosis of any unexplained chronic liver disease, especially in individuals younger than 40 years. The condition may also manifest as acute hepatitis. Hepatic dysfunction is the presenting feature in more than half of patients. The 3 major patterns of hepatic involvement are as follows:
(1) chronic active hepatitis,
(2) cirrhosis, and
(3) fulminant hepatic failure. The most common initial presentation is cirrhosis.
= CIRRHOSIS
Definitions of cirrhosis
noun
A chronic disease of the liver marked by degeneration of cells, inflammation, and fibrous thickening of tissue. It is typically a result of alcoholism or hepatitis.
Chronic viral hepatitis is the main cause of chronic liver disease, cirrhosis and hepatocellular carcinoma throughout the world.
ABOUT CHOLESTASIS (9/11/2016)
Cholestasis means any condition in which bile flow is reduced or stopped. "Chole" refers to bile and "stasis" means "not moving." Bile flow may be blocked inside the liver, outside the liver, or in both places. Symptoms may include:
Jaundice
Dark urine
Pale stool
Easy bleeding
Itching
Ascites
Chills
Pain from the biliary tract or pancreas
Enlarged gallbladder
Some causes of cholestasis include the following:
Hepatitis
Alcoholic liver disease
Primary biliary cirrhosis
Drug effects
Hormonal changes during pregnancy
A stone in the bile duct
Bile duct narrowing
Bile duct cancer
Pancreatic cancer
Inflammation of the pancreas
BILE DUCT CANCER (9/11/2016
The Bile duct with normal or healthy natural helix of DNA
Blood plasma = 7.4 pH
Urine = 4.6 to 8.0 pH
Healthy Helix height = 34A
Healthy Helix distance between two base pair = 3.4A
= a2 + b2 = c2
= a2 (helix height) + b2 (helix distance two base) = c2
= a2 34A + b2 3.4A = c2
= a2 1156 + b2 11.56 = c2
= a + b = 1167.56 = c2
= a + b = 1167.56 / 34.34 = 34.34
= a + b = 34.34 * 2.5 (H2= A//T DNA) = 85.85
= a + b = 85.85 * 3.75 (H3= C///G DNA) = 321.9375
= a + b = 321.9375 * 50 ratio = 16096.875
= a + b = 16096.875 / 458 (amino acids of alpha-globulin) = 35.14
= a + b = 35 / 7.4 pH (blood plasma) = 4.72
= a + b = 4.6 to 8.0 pH of urine.
The alpha-globulin protein has been tested for use as a cancer treatment that would activate macrophages against cancer cells,
Vitamin D-binding protein belongs to the albumin gene family, together with human serum albumin and alpha-fetoprotein. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues, As Gc protein-derived macrophage activating factor it is a Macrophage Activating Factor (MAF) that has been tested for use as a cancer treatment that would activate macrophages against cancer cells,
ALP - blood test
Alkaline phosphatase (ALP) is a protein found in all body tissues. Tissues with higher amounts of ALP include the liver, bile ducts, and bone.
A blood test can be done to measure the level of ALP.
A related test is the ALP isoenzyme test.
Phosphorus blood test
What Abnormal Results Mean
A higher than normal level (hyperphosphatemia) may be due to many different health conditions. Common causes include:
Diabetic ketoacidosis (life-threatening condition that may occur in people with diabetes)
Hypoparathyroidism (parathyroid glands do not make enough of their hormone)
Kidney failure
Liver disease
Too much vitamin D
Too much phosphate in your diet
Use of certain medicines such as laxatives that have phosphate in them
A lower than normal level (hypophosphatemia) may be due to:
Alcoholism,
BILE DUCT CANCER
The Bile duct with normal or healthy natural helix of DNA
Blood plasma = 7.4 pH
Urine = 4.6 to 8.0 pH
Healthy Helix height = 34A
Healthy Helix distance between two base pair = 3.4A
= a2 + b2 = c2
= a2 (helix height) + b2 (helix distance two base) = c2
= a2 34A + b2 3.4A = c2
= a2 1156 + b2 11.56 = c2
= a + b = 1167.56 = c2
= a + b = 1167.56 / 34.34 = 34.34
= a + b = 34.34 * 2.5 (H2= A//T DNA) = 85.85
= a + b = 85.85 * 3.75 (H3= C///G DNA) = 321.9375
= a + b = 321.9375 * 50 ratio = 16096.875
= a + b = 16096.875 / 80 % (organic compounds) = 201.2109375
= a + b = 201.21 / 6.2 pH (Sucrose enzyme of small intestine) = 32.45
= a + b = 33 / 8 pH (Trypsin enzyme of small intestine) = 4.125
= a + b = 4.125 pH of lipase enzymes of stomach,
The main function of bile acids is to allow digestion of dietary fats and oils by acting as a surfactant that emulsifies them into micelles, allowing them to be colloid-ally suspended in thechyme before further processing. They also have hormonal actions throughout the body, particularly through the farnesoid X receptor and GPBAR1 (also known as TGR5)
= a + b = 16096.875 / 7.4 pH (blood plasma) = 2175.25
= a + b = 2175 / 1.5 pH (pepsin enzyme) = 72.50
= a + b = 72.50 / 38.07A = 38.08A
= a + b = 38A = height of helix from reason of hot stomach,
COLORS BY WAVELENGTH FOR STOMACH
= a + b = 72.50 / 38.07A = 38.08A
Then 72.50 / 2A = 725
Now 725 = 38A
Now 725 = 38A
Therefore wave length = 725 (nm) = red + cyan = brown wavelength color
Then brown color = hot stomach
WAVELENGTH COLOR FOR BILE DUCT (9/16/2016)
= a + b = 72.50 / 38.07A = 38.08A
= a + b = 72.50 / 1.25 H1 = 1160
Then 1160 / 2A = 580
Now 580 = 34.05A
Now 580 = 34.06A normal height of helix
Wavelength 570–585 = yellow color + blue complementary colors
100 % yellow + 100 % blue complementary = dark green
(9/20/2016)
Now 580 nm = dark green
Now 72.5 nm = 12.5 % green = violet/brown
Wavelength = 72.5 (nm) = 12.5 % green = violet/brown
Then green color = Bile duct,
= a2 + b2 = Cancer
= a2 (12.5 % violet/brown bile duct) + b2 (Glucose) = c2
= a2 72.5 (nm) + 1393.25 (C6H12O6)7.61 = c2
= a2 5256.25 + b2 1941145.5625 = c2
= a + b = 1946401.8125 = ->Nucleic acid<-
= a + b = 1946401.8125 = c2
= a + b = 1946401.8125 / 1395.13 = 1395.14
= a + b = 1395.14 / 22.502 (H2O + H4) = 62
= a + b = 62 = ->P2<-
= a + b = 1395.14 = ->Amino acids<-
= a + b = 1946401.8125 / 1395.13 = 1395.14
A
= a + b = 1395.14 / 158 (amino acid) = 8.83
= a + b = 8.83 pH of lipid (ester bond) from lipase enzyme of pancreas,
= a + b = 8.83 * 6 (E6) = 53 proteins
So the 12.5 % green color is equal to violet/brown of a little spot in bile duct,
Now 72.5 nm = 12.5 % violet/brown color = 1393.25 (C6H12O6)7.61 = glucose in bile fluid
Now 72.5 nm = E6 = 53 proteins
Glucose = 1393.25 mol
ATP formula = C10H16N5O13P3 = 511 energy
Glucose = 1393.25 / 511 = 2.72
= 2.72 – P2 = 0.72 fructose
Or
oncoproteins
--------------
<---------------
Fructose 0.72 P2 = Tumor M2-PK
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Pyruvate = EC number 1.2, 4.1,
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= 511 / 1.2 = 425.83
= 425.83 / 2.72 tumor = 156.55
= 156.55 - 8.05 pH domain dimer = 148.5
= 148.5 = Glutamine
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Lactate -------------------- Glutamine
DNA CONDITION OF BILE DUCT CANCER
A
= a + b = 1395.14 / 2.5 (H2= A//T DNA) = 558.056
= a + b = 558.056 / 3.75 (H3= C///G DNA) = 148.81
= a + b = 148.81 - 0.31 = 148.5
= a + b = 148.5 = Glutamine
= a + b = 148.81 / E6 Tumor = 24.80
= a + b = 24.80 * 50 ratio = 1240
= a + b = 1240 / 35.21A = 35.21A
= 35A the height of helix
= 35A / 10 mononucleotide = 3.5
= 3.5A distance between two base pair
MUTATION RATE OF M2-PK
Hydrogen healthy size = 1.25 m/g
10 micrometer = 1000 gene
DNA 35A height / 34A height = 1.02 value of H1
DNA 35A height / 34A height = 1.02 value of H1
= ----------------- +
2.04 value of H2
Micrometer = 10 * 1000 = 10000
= 10000 * 24 hours = 240000
= 240000 * 2.04 H2 = 489600
= 489600, gene of two base pair,
Two base pair = 489600 – 300000 healthy gene of H1 = 189600
= 189600 - 300000 healthy gene of H1 = -110400
= 0.000001 gene = mutation by value of H2
= 0.000001 gene = tumor suppressor genes
In bacteria, a form of pyruvate dehydrogenase (also called pyruvate oxidase, EC 1.2.2.2) exists that links the oxidation of pyruvate into acetate and carbon dioxide to the reduction of ferrocytochrome. In E. coli this enzyme is encoded by the pox B gene and the protein has a flavin cofactor, this enzyme increases the efficiency of growth of E. coli under aerobic conditions,
The E6 protein consists of 158 amino acid residues and contains two zinc-finger binding motifs (2). The E6 protein is thought to promote cell proliferation by stimulating degradation of the tumor suppressor p53 protein via the formation of a trimeric complex comprising E6, p53 and the cellular ubiquitination enzyme E6-AP.
E6-stimulated degradation interferes with such biological functions of p53; thus perturbing the control of cell cycle progression, leading finally to increased tumor cell growth (3). Although it is commonly accepted that the ability of high-risk type HPV E6 to target p53 for degradation contributes to virus-induced cellular transformation, it is also clear that the E6 protein has ontogeny activities that are independent of p53.
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