(Two Polynucleotide in mathematical machine of Sikander Aqeel)
WILSON DISEASE
Lower-than-normal ALP levels
1 = Hypophosphatasia
2 = Malnutrition
3 = Wilson disease
Wilson disease has a range of clinical manifestations, from an asymptomatic state to fulminate hepatic failure, chronic liver disease with or without cirrhosis, neurologic, and psychiatric manifestations
Consider hepatic Wilson disease in the differential diagnosis of any unexplained chronic liver disease, especially in individuals younger than 40 years. The condition may also manifest as acute hepatitis. Hepatic dysfunction is the presenting feature in more than half of patients. The 3 major patterns of hepatic involvement are as follows:
(1) chronic active hepatitis,
(2) cirrhosis, and
(3) fulminant hepatic failure. The most common initial presentation is cirrhosis.
= CIRRHOSIS
Definitions of cirrhosis
noun
A chronic disease of the liver marked by degeneration of cells, inflammation, and fibrous thickening of tissue. It is typically a result of alcoholism or hepatitis.
Chronic viral hepatitis is the main cause of chronic liver disease, cirrhosis and hepatocellular carcinoma throughout the world.
ABOUT CHOLESTASIS (9/11/2016)
Cholestasis means any condition in which bile flow is reduced or stopped. "Chole" refers to bile and "stasis" means "not moving." Bile flow may be blocked inside the liver, outside the liver, or in both places. Symptoms may include:
Jaundice
Dark urine
Pale stool
Easy bleeding
Itching
Ascites
Chills
Pain from the biliary tract or pancreas
Enlarged gallbladder
Some causes of cholestasis include the following:
Hepatitis
Alcoholic liver disease
Primary biliary cirrhosis
Drug effects
Hormonal changes during pregnancy
A stone in the bile duct
Bile duct narrowing
Bile duct cancer
Pancreatic cancer
Inflammation of the pancreas
A STONE IN THE BILE DUCT (9/23/2016)
The stone in bile duct as hard calcium, Magnesium, and Uric Acid type material,
TOTAL ACIDS OF BILE DUCT
Glycocholic acid, Cholic acid, Taurocholic acid, Deoxycholic acid, Chenodeoxycholic acid, Glycochenodeoxycholic acid, Taurochenodeoxycholic acid, Lithocholic acid,
BILE DUCT COLOR AND CHEMICALS
Glycocholic acid = C26H43NO6 = 465.631 g/mol
Dark Green color = 580 (nm)
TOTAL NEED OF GLYCOCHOLIC ACID AND COLOR IN BILE DUCT
For percentage
Glycocholic acid = 465.631 / 100 % = 4.65631
= 4.65631 * 34.600 % = 161.11
= 161.11 mole = 34.600 % Glycocholic acid
Need of Glycocholic acid = 161.11 mole
Need of bile duct color = 145 (nm) = 25 % green color
= a2 + b2 = c2
= a2 (Glycocholic acid) + b2 (25 % Green color) = c2
= a2 161.11 g/mol + b2 145 (nm) = c2
= a2 25956.4321 + b2 21025 = c2
= a + b = 46981.4321 = c2
= a + b = 46981.4321 / 216.75 = 216.75
A About stone in bile duct
= a + b = 216.75 / 18.5 (H2O) = 11.71, Carbon and not stone in bile duct
= a + b = 216.75 / 30.99 (P1) = 6.99, H7 and not stone in bile duct
= a + b = 216.75 / 4.40 pH (of Lipase enzyme) = 49.26, 2H2O + C and not stone in bile duct
B Condition of DNA
= a + b = 216.75 / 2.5 (H2= A//T DNA) = 86.7
= a + b = 86.7 / 3.75 (H3= C///G DNA) = 23.12
= a + b = 23.12 * 50 ratio = 1156
= a + b = 1156 / 34A = 34A
= a + b = 34A, normal height of DNA helix by use of nitrogen acid
= a + b = 34A / 10 mononucleotide = 3.4
= a + b = 3.4A, normal distance between two base pair
MUTATION BY 2.5 H2
34A normal height = 1.25 of H1
34A normal height = 1.25 of H1
= ----------------- +
2.5 value of H2
Micrometer = 10 * 1000 = 10000
= 10000 * 24 hours = 240000
= 240000 * 2.5 H2 = 600000
= 600000, gene of two base pair,
Two base pair = 600000 – 300000 healthy gene of H1 = 300000
= 300000 - 300000 healthy gene of H1 = 0
= 0 gene = zero mutation in bile duct from reason of 34A and 3.4A value of DNA helix,
So 161.11 mole Glycocholic acid is a need of bile duct for healthy functions, with 25 % color of bile duct,
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