NARROWING OF BILE DUCT,

(Two Polynucleotide in mathematical machine of Sikander Aqeel) 

WILSON DISEASE 

Lower-than-normal ALP levels 

1 = Hypophosphatasia 

2 = Malnutrition 

3 = Wilson disease 

Wilson disease has a range of clinical manifestations, from an asymptomatic state to fulminate hepatic failure, chronic liver disease with or without cirrhosis, neurologic, and psychiatric manifestations

Consider hepatic Wilson disease in the differential diagnosis of any unexplained chronic liver disease, especially in individuals younger than 40 years. The condition may also manifest as acute hepatitis. Hepatic dysfunction is the presenting feature in more than half of patients. The 3 major patterns of hepatic involvement are as follows: 

(1) Chronic active hepatitis, 

(2) Cirrhosis, and 

(3) fulminate hepatic failure. The most common initial presentation is cirrhosis. 

= CIRRHOSIS  

Definitions of cirrhosis

Noun

A chronic disease of the liver marked by degeneration of cells, inflammation, and fibrous thickening of tissue, It is typically a result of alcoholism or hepatitis.

Chronic viral hepatitis is the main cause of chronic liver disease, cirrhosis and hepatocellular carcinoma throughout the world.

ABOUT CHOLESTASIS 

Cholestasis means any condition in which bile flow is reduced or stopped. "Chole" refers to bile and "stasis" means "not moving." Bile flow may be blocked inside the liver, outside the liver, or in both places. Symptoms may include:

Jaundice = ~

Dark urine = ~

Pale stool

Easy bleeding

Itching

Ascites 

Chills

Pain from the biliary tract or pancreas

Enlarged gallbladder

Some causes of cholestasis include the following:

Hepatitis

Alcoholic liver disease = ~

Primary biliary cirrhosis

Drug effects

Hormonal changes during pregnancy

A stone in the bile duct

Bile duct narrowing = ~

Bile duct cancer = ~

Pancreatic cancer

Inflammation of the pancreas 

BILE DUCT NARROWING (10/21/2016) 

The bile duct narrowing begins from inflammation of bile duct cells, when wavelength value or color becomes dark,   

TOTAL ACIDS OF BILE DUCT 

Glycocholic acid, Cholic acid, Taurocholic acid, Deoxycholic acid, Chenodeoxycholic acid, GlycochenoChenodeoxycholic acid, TaurochenoChenodeoxycholic acid, Lithocholic acid,    

BILE DUCT COLOR AND CHEMICALS

Taurocholic acid = C26H44NNaO7S = 537.68 g/mol

Dark Green color = 580 (nm) = 100 % 

         = a2 + b2 = c2 

         = a2 (100 % Taurocholic acid)  + b2 (100 % Green color) = c2  

         = a2 537.68 g/mol             + b2 580 (nm) = c2 

         = a2 289099.7824              + b2 336400 = c2 

         = a + b = 625499.7824 = c2     

         = a + b = 625499.7824 / 790.88 = 790.89

         A Condition of DNA

         = a + b = 790.89 / 2.5 (H2= A//T DNA) = 316.356

         = a + b = 316.356 / 3.75 (H3= C///G DNA) = 84.3616

         = a + b = 84.3616 * 50 ratio = 4218.08

         = a + b = 4218.08 / 64.94A = 64.95A

         = a + b = 65A, height of DNA helix with inflammation, 

         = a + b = 65A, - 34A original DNA = 31 % inflammation, 

         = a + b = 65A, - 34A original DNA = 31 % narrowing of bile duct from Taurocholic acid, 

So the narrowing of bile duct = 31 % from over Taurocholic acid, 

So the narrowing of bile duct = 27 % from over Deoxycholic acid,  

So the narrowing of bile duct = 27 % from over ChenoTaurocholic acid,  

So the narrowing of bile duct = 29 % from over GlycochenoTaurocholic acid  

So the narrowing of bile duct = 30 % from over TaurochenoTaurocholic acid, 

So the narrowing of bile duct = 27 % from over Lithocholic acid,